Prostate Cancer Clinical Trial
Official title:
Robotic Surgery After Focal Ablation Therapy
The toxicity of traditional prostate cancer therapies including radical surgery and external
beam radiation is well known. This has prompted a move towards focal therapy where only the
cancerous part of the prostate is treated.
To date, studies have demonstrated very promising outcomes following focal therapy with the
majority of men maintaining their urinary and sexual function after therapy.
In a small proportion of men, disease recurs after focal therapy. The optimal treatment for
men with recurrent disease after focal therapy is yet to be defined. Patients may undergo
further focal therapy to the recurrent disease, undergo radiation therapy, whole-gland
therapy using a minimally invasive approach such as High Intensity Focused Ultrasound (HIFU)
or cryotherapy. Alternatively patients may undergo radical surgery where the whole prostate
is removed.
To date, the side-effects or toxicity of any treatment for recurrent prostate cancer after
focal therapy has not been formally studied.
Traditionally, the side effects of surgery and radiation therapy performed in patients that
have already undergone previous prostate cancer treatment have been considerable with high
rates of urinary incontinence and erectile dysfunction. However, as focal therapy leaves a
significant area of the prostate untreated, the investigators believe surgery after focal
prostate therapy will be associated with a much lower incidence of urinary and sexual
dysfunction.
The aim of the RAFT study is to characterise the side effects of prostate cancer surgery in
men that have undergone prior focal ablation therapy. In addition, the investigators wish to
perform a number of basic science studies to attempt to better understand why the patient has
experienced recurrent prostate cancer after focal therapy.
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