Prostate Cancer Clinical Trial
Official title:
A Pre-Biopsy Window of Opportunity Trial to Measure Sulphate Levels in Human Prostate After Broccoli Consumption
This study evaluates whether a broccoli intervention (≥ 4 weeks) will result in differences in tissue sulphate levels in men scheduled for prostate biopsies. Comparisons will be made between participants randomised to the broccoli-rich diet and those randomised to the non-intervention arm.
Epidemiological studies provide evidence for a negative correlation between prostate cancer
and intake of cruciferous vegetables such as broccoli. Preliminary data from ongoing
intervention trials carried out at the IFR suggest that dietary changes can directly
influence the metabolic profile of prostate tissue. The most significant result observed to
date is that of sulphate accumulation within the prostate. The additional sulphate is likely
to drive synthesis of 3'-phosphoadenosine-5'-phosphosulfate, a universal sulphate donor, a
process which would consume energy from ATP. A significant rise in levels of both ADP and
phosphate has also been observed in prostate tissue from these studies, supporting the
potential depletion of cellular ATP. Interestingly, the data indicate that the extent of ADP
accumulation is negatively correlated with prostate cancer progression.
The investigators now propose to undertake a two arm parallel un-blinded study to test the
hypothesis that a short-term intervention with broccoli soups will lead to the accumulation
of sulphate and ADP in prostate tissue. A potential increase in glutathione metabolites
indicating a change in redox status, and therefore functional status, of specific genes
involved in tumour suppression (PTEN) will also be investigated.
Furthermore, the investigators aim to determine whether the accumulation of sulphate and ADP
is specific to the prostate gland through the metabolic analyses of both prostate and
non-prostate tissues.
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