Prostate Cancer Clinical Trial
Official title:
The Predictive Value of TMPRSS2-ERG Fusion in High Risk Prostate Cancer Patient
The objective of this study is to evaluate the predictive value of TMPRSS2-ERG gene fusion in patients with prostate cancer treated with radiation and hormonal therapy.
The objective of this study is to evaluate the predictive value of TMPRSS2-ERG gene fusion
in prostate patients who have been treated with hormonal and radiation treatment after
biochemical failure
Original biopsy slides of 65 patients will be collected and reviewed. A tissue used to test
and map DNA fragments will be constructed from patients who underwent radiation therapy. RNA
and DNA will be extracted from each slide. This study, if positive, will establish the
predictive value of TMPRSS2-ERG gene fusion in prostate cancer patients. It can lead to
believe that high-risk prostate cancer patients will benefit from a more aggressive
treatment.
An endpoint of this study is to evaluate the relation between the Gleason score and the
TMPRSS2-ERG gene fusion. Another is to evaluate the relation between the T-stage and
TMPRSS2-ERG gene fusion.
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Observational Model: Case-Only, Time Perspective: Prospective
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