Prostate Cancer Clinical Trial
Sympathetic activity could be increased during robot-assisted laparoscopic radical
prostatectomy, which is performed in a steep trendelenburg position under CO2
pneumoperitoneum.
Stimulation of the sympathetic nervous system prolongs the QT interval and can increases the
susceptibility to life threatening cardiac arrhythmias.
Dexmedetomidine has sympatholytic effects and potential antiarrhythmic properties.
Perioperative administration of dexmedetomidine is a potential preventive and treatment
strategy for tachyarrhythmia. Thus the investigators decided to evaluate the effect of
dexmedetomidine on heart-rate corrected QT interval during robot-assisted laparoscopic
radical prostatectomy. Furthermore, the investigators evaluated the Tp-e, Tp-e/QT ratio and
Tp-e/QTc ratio as well.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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