Prostate Cancer Clinical Trial
Official title:
Targeted Biopsies and the Role of Cytological Imprints for Diagnosis of Prostate Cancer
The investigators will evaluate the accuracy of performing cytological imprints of targeted
biopsies when diagnosing prostate cancer.
It is useful to know whether the biopsy is cancer or not, in order to know when to stop
sampling and when to continue.
The strategy is used in other types of cancer, e.g lung, breast etc
Background:
When substituting a random biopsy procedure with a few targeted biopsies, it is of outmost
importance to know immediately if the biopsy is positive or not. A recent study has
demonstrated a high sensitivity and specificity of imprint cytology of random biopsies.
Aim:
The correlation between cytological imprints and histology of targeted prostate biopsies
Material&Method:
All patients in this study are already participating in an ongoing randomized biopsy study
(NCT01455792) comparing:
1. Preoperative MRI and targeted biopsies + random biopsies .
2. Random biopsies (gold standard).
Only patients with a positive MRI were included in this collateral study.
The cytological imprints (negative/positive) of each targeted biopsy is compared to the
histology (negative/positive) and Gleason score.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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