Prostate Cancer Clinical Trial
— UKGPCSOfficial title:
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
The UKGPCS was set up to find genetic alterations which occur in patients who have prostate cancer. A man's risk of developing prostate cancer increases if he has a first-degree relative (father or brother) who was diagnosed with prostate cancer at a young age. This is why we are looking for men who are affected at a young age or who have a family history of prostate cancer, since it is more probable that these prostate cancers are due to an inherited genetic cause rather than an environmental cause. We also ask all men who come to the Royal Marsden Hospital to be treated for prostate cancer if they would like to take part in the study so that we can also look to see if we find genetic alterations in older men, and those who do not have a family history of prostate cancer.
Status | Recruiting |
Enrollment | 26000 |
Est. completion date | December 2027 |
Est. primary completion date | December 2027 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Man with PrCa at any age at diagnosis at Royal Marsden NHS Foundation Trust - Those outside the Royal Marsden NHS Foundation Trust with - PrCa at or below 60 years at diagnosis - PrCa in first-degree related pairs where one is = 65 years at diagnosis - PrCa at any age in a cluster with 3 or more cases - Those able to understand the information sheet and give informed consent (language line is available for those who wish to have translation) - Any unaffected relatives of men who are already taking part in the study Exclusion Criteria: - Man with PrCa who is too ill to take part |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Institute of Cancer Research and Royal Marsden Hospital | Sutton | Surrey |
Lead Sponsor | Collaborator |
---|---|
Institute of Cancer Research, United Kingdom | Cancer Research UK, Royal Marsden NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To find genes which predispose to PrCa | 2017 |
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