Prostate Cancer Clinical Trial
Official title:
Focal Therapy With Magnetic Resonance Guided Focused Ultrasound Treatment of Locally Non-Advanced Prostate Cancer: Phase 1 Study
Since prostate specific antigen (PSA) was introduced as a clinical screening tool for
prostate cancer, more men are diagnosed with small foci of cancers instead of the advanced
disease. The present choice of treatment for men with localized prostate cancer lies between
active surveillance and radical therapy. Thus, the option of treating only the cancer within
the prostate gland and sparing the non-cancerous tissue is quite appealing, yet very
controversial. At present there are no consistent scientific data on focal therapy and its
major effectiveness.
Focal therapy for prostate cancer is defined as therapy that selectively ablates known
disease while preserving existing functions, with the overall aim of minimizing lifetime
morbidity without compromising life expectancy.
The aim of the investigators study is to test if Magnetic Resonance guided Focused
Ultrasound ablation can determine non-invasive necrosis of focal, locally non-advanced
prostate cancer.
The study i designed as Phase 1, treatment & resection protocol. With this project the
investigators further aim to evaluate the safety and identify side effects of Magnetic
Resonance guided Focused Ultrasound in treating focal prostate cancer.
This design will also expand knowledge of the effect of Magnetic Resonance guided Focused
Ultrasound onto peri-prostatic environment and to determine if surgery can safely be adopted
after this non-invasive treatment.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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