Prostate Cancer Clinical Trial
Official title:
Does Androgen Suppression Treatment In Prostate Cancer Reduce Myocardial Blood Flow Reserve?
Suppression of effects of androgens with male sex hormones, androgen suppression treatment (AST), has been known to reduce deaths and prolong life in advanced prostate cancer. There have, however, been concerns raised in previous studies that androgen suppression may be associated with increased rate of heart attacks, particularly in older men. This study looks at prostate cancer patients in The Ottawa Hospital Cancer Clinic to see if treating these patients with androgen suppression is associated with a decrease in blood flow to the heart muscles by using Positron Emission Tomography (PET) and brachial artery ultrasound.
Treatment group: Prior to the initiation of AST, subjects will have a baseline N-13-ammonia
PET scan and a brachial artery ultrasound at the University of Ottawa Heart Institute. Blood
glucose and a lipid profile will be obtained. These tests will be repeated 6 - 9 months
after starting AST.
Cancer control group: The same testing and intervals will be performed. Normals control
group: Baseline testing will be done to establish a normal.
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