Prostate Cancer Clinical Trial
Official title:
Germline Polymorphisms Associated With the PSA Response in Men With Metastatic Prostate Cancer Treated With Androgen Deprivation Therapy
RATIONALE: Studying samples of blood in the laboratory from patients with cancer may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is studying blood samples from patients with metastatic
prostate cancer previously treated with bicalutamide and goserelin.
OBJECTIVES:
- To test the association between serum PSA response (< 4 ng/mL) at 7 months with
inherited variability of germline single nucleotide polymorphisms, in a set of
candidate genes, in patients with metastatic prostate cancer treated with combination
induction androgen-deprivation therapy comprising bicalutamide and goserelin.
OUTLINE: DNA extracted from whole blood or serum samples is analyzed for inherited
variability of germline single nucleotide polymorphisms.
;
Observational Model: Cohort, Time Perspective: Retrospective
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