Prostate Cancer Clinical Trial
Official title:
Hypoxia Assessment in Localized Prostate Cancer: A Companion Protocol to a Phase II Study of Stereotactic Body Radiation Therapy (SBRT) for Low and Intermediate Risk Prostate Cancer
RATIONALE: Diagnostic procedures, such as MRI, may help measure oxygen levels in tumor cells.
It may also help doctors predict a patient's response to treatment and help plan the best
treatment.
PURPOSE: This clinical trial is studying how well MRI works in assessing hypoxia in patients
with localized prostate cancer undergoing stereotactic body radiation therapy.
OBJECTIVES:
- To characterize the status of global hypoxia within the prostate before stereotactic
body radiotherapy (SBRT) as assessed by blood-oxygen-level-dependent and
tissue-oxygen-level-dependent MRI.
- To characterize tumor vasculature and metabolism within the prostate before SBRT as
assessed by dynamic contrast-enhanced MRI and magnetic resonance spectroscopic imaging,
respectively.
- Correlate prostate and normal tissue hypoxia before SBRT with clinical outcomes
(toxicity and biochemical [PSA] control) after SBRT.
OUTLINE: Within 1-3 weeks before beginning stereotactic body radiotherapy, patients undergo
T2-weighted anatomic MRI, magnetic resonance spectroscopic imaging,
blood-oxygen-level-dependent and tissue-oxygen-level-dependent MRI, and dynamic
contrast-enhanced MRI.
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