Prostate Cancer Clinical Trial
Official title:
UK Genetic Prostate Cancer Study
Verified date | August 2009 |
Source | National Cancer Institute (NCI) |
Contact | n/a |
Is FDA regulated | No |
Health authority | Unspecified |
Study type | Observational |
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify genes
related to cancer.
PURPOSE: This clinical trial is studying blood and tumor samples from men with an inherited
risk of prostate cancer.
Status | Recruiting |
Enrollment | 21000 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Male |
Age group | N/A and older |
Eligibility |
DISEASE CHARACTERISTICS: - Meets 1 of the following criteria: - Diagnosis of prostate cancer meeting any of the following criteria: - Attending prostate clinics at The Royal Marsden NHS Foundation Trust - Any age at diagnosis - Not attending prostate clinics at The Royal Marsden NHS Foundation Trust, meeting 1 of the following criteria: - No older than 60 years at diagnosis - Diagnosis in two relatives where one is = 65 years at diagnosis - At any age in a cluster with 3 or more cases - Any unaffected male relatives of men who are already taking part in the study PATIENT CHARACTERISTICS: - Able to understand the information sheet and give informed consent - No man who is too ill to take part PRIOR CONCURRENT THERAPY: - Not specified |
N/A
Country | Name | City | State |
---|---|---|---|
United Kingdom | Aberdeen Royal Infirmary | Aberdeen | Scotland |
United Kingdom | William Harvey Hospital | Ashford-Kent | England |
United Kingdom | Tameside General Hospital | Ashton-Under-Lyne | England |
United Kingdom | Stoke Mandeville Hospital | Aylesbury-Buckinghamshire | England |
United Kingdom | Ayr Hospital | Ayr | Scotland |
United Kingdom | North Devon District Hospital | Barnstaple | England |
United Kingdom | Furness General Hospital | Barrow in Furness | England |
United Kingdom | Basildon University Hospital | Basildon | England |
United Kingdom | Basingstoke and North Hampshire NHS Foundation Trust | Basingstoke | England |
United Kingdom | Royal United Hospital | Bath | England |
United Kingdom | Primrose Centre at Bedford Hospitals NHS Trust | Bedford | England |
United Kingdom | Belfast City Hospital Trust Incorporating Belvoir Park Hospital | Belfast | Northern Ireland |
United Kingdom | Birmingham Heartlands Hospital | Birmingham | England |
United Kingdom | City Hospital - Birmingham | Birmingham | England |
United Kingdom | Good Hope Hospital | Birmingham | England |
United Kingdom | Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust | Birmingham | England |
United Kingdom | Royal Blackburn Hospital | Blackburn | England |
United Kingdom | Blackpool Victoria Hospital | Blackpool | England |
United Kingdom | Pilgrim Hospital | Boston | England |
United Kingdom | Royal Bournemouth Hospital | Bournemouth | England |
United Kingdom | Princess of Wales Hospital | Bridgend | Wales |
United Kingdom | Sussex Cancer Centre at Royal Sussex County Hospital | Brighton | England |
United Kingdom | Bristol Royal Infirmary | Bristol | England |
United Kingdom | Frenchay Hospital | Bristol | England |
United Kingdom | Southmead Hospital | Bristol | England |
United Kingdom | Broomfield Hospital | Broomfield | England |
United Kingdom | Burnley General Hospital | Burnley | England |
United Kingdom | Queen's Hospital | Burton-upon-Trent | England |
United Kingdom | Addenbrooke's Hospital | Cambridge | England |
United Kingdom | Kent and Canterbury Hospital | Canterbury | England |
United Kingdom | University Hospital of Wales | Cardiff | Wales |
United Kingdom | Velindre Cancer Center at Velindre Hospital | Cardiff | Wales |
United Kingdom | St. Helier Hospital | Carshalton | England |
United Kingdom | Countess of Chester Hospital | Chester | England |
United Kingdom | Colchester General Hospital | Colchester | England |
United Kingdom | Castle Hill Hospital | Cottingham | England |
United Kingdom | Walsgrave Hospital | Coventry | England |
United Kingdom | Mid Cheshire Hospitals Trust- Leighton Hopsital | Crewe | England |
United Kingdom | Mayday University Hospital | Croydon | England |
United Kingdom | Darent Valley Hospital | Dartford Kent | England |
United Kingdom | Derbyshire Royal Infirmary | Derby | England |
United Kingdom | Royal Derby Hospital | Derby | England |
United Kingdom | Dorset County Hospital | Dorchester | England |
United Kingdom | Downe Hospital | Downpatrick | Northern Ireland |
United Kingdom | Russells Hall Hospital | Dudley | England |
United Kingdom | Eastbourne District General Hospital | Eastbourne | England |
United Kingdom | Birmingham Women's Hospital | Edgbaston | England |
United Kingdom | Epsom General Hospital | Epsom, Surrey | England |
United Kingdom | Royal Devon and Exeter Hospital | Exeter | England |
United Kingdom | Falkirk and District Royal Infirmary | Falkirk | Scotland |
United Kingdom | Royal Bolton Hospital | Farnworth | England |
United Kingdom | Frimley Park Hospital | Frimley | England |
United Kingdom | Western Infirmary | Glasgow | Scotland |
United Kingdom | Grantham and District Hospital | Grantham, Lincolnshire | England |
United Kingdom | Diana Princess of Wales Hospital | Grimsby | England |
United Kingdom | Harrogate District Hospital | Harrogate | England |
United Kingdom | Wycombe General Hospital | High Wycombe | England |
United Kingdom | Princess Royal Hospital at Hull and East Yorkshire NHS Trust | Hull | England |
United Kingdom | Ipswich Hospital | Ipswich | England |
United Kingdom | Kidderminster Hospital | Kidderminster Worcestershire | England |
United Kingdom | Royal Albert Edward Infirmary | Lancanshire | England |
United Kingdom | Royal Lancaster Infirmary | Lancaster | England |
United Kingdom | Cookridge Hospital | Leeds | England |
United Kingdom | Leeds Cancer Centre at St. James's University Hospital | Leeds | England |
United Kingdom | Leeds General Infirmary | Leeds | England |
United Kingdom | Leicester General Hospital | Leicester | England |
United Kingdom | Leicester Royal Infirmary | Leicester | England |
United Kingdom | Lincoln County Hospital | Lincoln | England |
United Kingdom | Royal Liverpool University Hospital | Liverpool | England |
United Kingdom | Charing Cross Hospital | London | England |
United Kingdom | Guy's Hospital | London | England |
United Kingdom | Hammersmith Hospital | London | England |
United Kingdom | Middlesex Hospital | London | England |
United Kingdom | Royal London Hospital | London | England |
United Kingdom | Saint Bartholomew's Hospital | London | England |
United Kingdom | St. Mary's Hospital | London | England |
United Kingdom | Whipps Cross Hospital | London | England |
United Kingdom | Altnagelvin Area Hospital | Londonderry | Northern Ireland |
United Kingdom | Macclesfield District General Hospital | Macclesfield | England |
United Kingdom | Maidstone Hospital | Maidstone | England |
United Kingdom | Christie Hospital | Manchester | England |
United Kingdom | Clatterbridge Centre for Oncology | Merseyside | England |
United Kingdom | James Cook University Hospital | Middlesbrough | England |
United Kingdom | Milton Keynes General Hospital | Milton Keynes | England |
United Kingdom | Queen Victoria Hospital | Morecambe | |
United Kingdom | Newcastle Upon Tyne Hospitals NHS Trust | Newcastle-Upon-Tyne | England |
United Kingdom | Royal Gwent Hospital | Newport Gwent | Wales |
United Kingdom | Mount Vernon Cancer Centre at Mount Vernon Hospital | Northwood | England |
United Kingdom | Norfolk and Norwich University Hospital | Norwich | England |
United Kingdom | Nottingham City Hospital | Nottingham | England |
United Kingdom | Kings Mill Hospital | Nottinghamshire | England |
United Kingdom | George Eliot Hospital | Nuneaton | England |
United Kingdom | Churchill Hospital | Oxford | England |
United Kingdom | Edith Cavell Hospital | Peterborough | |
United Kingdom | Peterborough Hospitals Trust | Peterborough | England |
United Kingdom | Derriford Hospital | Plymouth | England |
United Kingdom | Dorset Cancer Centre | Poole Dorset | England |
United Kingdom | Craigavon Area Hospital | Portadown, Craigavon | Northern Ireland |
United Kingdom | Rosemere Cancer Centre at Royal Preston Hospital | Preston | England |
United Kingdom | Berkshire Cancer Centre at Royal Berkshire Hospital | Reading | England |
United Kingdom | Alexandra Healthcare NHS | Redditch, Worcestershire | England |
United Kingdom | Glan Clwyd Hospital | Rhyl, Denbighshire | Wales |
United Kingdom | Queens Hospital | Romford | England |
United Kingdom | Conquest Hospital | Saint Leonards-on-Sea | England |
United Kingdom | Hope Hospital | Salford | England |
United Kingdom | Salisbury District Hospital | Salisbury | England |
United Kingdom | Scarborough General Hospital | Scarborough | England |
United Kingdom | Scunthorpe General Hospital | Scunthorpe | England |
United Kingdom | Southlands Hospital | Shoreham-by-Sea | |
United Kingdom | Royal Shrewsbury Hospital | Shrewsbury | England |
United Kingdom | Wexham Park Hospital | Slough, Berkshire | England |
United Kingdom | Solihull Hospital | Solihull | England |
United Kingdom | Princess Anne Hospital | Southampton | |
United Kingdom | Southampton General Hospital | Southampton | England |
United Kingdom | Southport and Formby District General Hospital | Southport | England |
United Kingdom | Staffordshire General Hospital | Stafford | England |
United Kingdom | Lister Hospital | Stevenage | England |
United Kingdom | Stirling Royal Infirmary | Stirling | England |
United Kingdom | Stepping Hill Hospital | Stockport | England |
United Kingdom | East Surrey Hospital | Surrey | England |
United Kingdom | Kingston Hospital | Surrey | England |
United Kingdom | Royal Marsden - Surrey | Sutton | England |
United Kingdom | Singleton Hospital | Swansea | Wales |
United Kingdom | Great Western Hospital | Swindon | England |
United Kingdom | Taunton and Somerset Hospital | Taunton | England |
United Kingdom | Torbay Hospital | Torquay | England |
United Kingdom | Hillingdon Hospital | Uxbridge | England |
United Kingdom | Pinderfields General Hospital | Wakefield | Scotland |
United Kingdom | Warwick Hospital | Warwick | England |
United Kingdom | Sandwell General Hospital | West Bromwich | England |
United Kingdom | Southend University Hospital NHS Foundation Trust | Westcliff-On-Sea | England |
United Kingdom | New Cross Hospital | Wolverhampton | England |
United Kingdom | Worthing Hospital | Worthing | England |
United Kingdom | Yeovil District Hospital | Yeovil | England |
United Kingdom | Cancer Care Centre at York Hospital | York | England |
Lead Sponsor | Collaborator |
---|---|
Institute of Cancer Research, United Kingdom |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prostate cancer (PC) predisposition (PCP) genes | No | ||
Secondary | Association of PCP genes with disease and treatment parameters | No | ||
Secondary | Association of PCP with environmental factors | No | ||
Secondary | Family history of PC | No | ||
Secondary | Relative risk of developing PC | No | ||
Secondary | Increased risk relatives of PC patients are to develop cancers other than PC | No | ||
Secondary | Markers of PC that are associated with PCP genes | No | ||
Secondary | Specific tumor genetic profile correlated with PCP genes | No |
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