Prostate Cancer Clinical Trial
Official title:
Phase II Trial of R115777 (NSC 702818) an Inhibitor of Farnesyl Protein Transferase, in Patients With Hormone Refractory Prostate Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of R115777 in treating patients who have
progressive, metastatic prostate cancer that has not responded to hormone therapy.
OBJECTIVES: I. Determine whether R115777 has any antitumor activity in patients with
progressive, metastatic, hormone refractory prostate cancer. II. Determine the safety and
pharmacokinetics of this regimen in this patient population.
OUTLINE: Patients receive oral R115777 every 12 hours on days 1-21. Courses repeat every 4
weeks in the absence of disease progression or unacceptable toxicity. Patients are followed
every 3 months.
PROJECTED ACCRUAL: A total of 15-30 patients will be accrued for this study within 10-16
months.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Primary Purpose: Treatment
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