Paclitaxel and Bryostatin 1 in Treating Patients With Metastatic Prostate Cancer

Prostate Cancer Clinical Trial

Official title:

Phase II Study of Weekly Paclitaxel and Bryostatin-1 in Hormone Refractory Prostate Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00005028
• Other study ID #: MSGCC-9948
• Secondary ID: CDR0000067549NCI
• Status: Completed
• Phase: Phase 2
• Start date: May 2000
• Est. completion date: July 2006

Study information

• Verified date: October 2019
• Source: University of Maryland, Baltimore
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Phase II trial to study the effectiveness of combining paclitaxel and bryostatin 1 in treating patients who have metastatic prostate cancer that has not responded to hormone therapy. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

Description:

OBJECTIVES:

I. Determine the onset, duration, and degree of response in patients with hormone-refractory, metastatic adenocarcinoma of the prostate treated with paclitaxel and bryostatin 1.

II. Determine the toxicity of this regimen in these patients. III. Determine the overall survival of patients treated with this regimen.

OUTLINE: This is an open-label, multicenter study.

Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and bryostatin 1 IV over 1 hour on days 2, 9, and 16. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.

Patients are followed monthly for 6 months and then every 3 months thereafter.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: July 2006
• Est. primary completion date: July 2006
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed metastatic adenocarcinoma of the prostate that failed first- or second-line hormonal therapy (e.g., gonadal androgen suppression [orchiectomy or luteinizing hormone-releasing hormone] with or without antiandrogens)

• Failure on hormonal therapy is defined by 1 of the following criteria:

• Biochemical progression (after withdrawal of antiandrogens), documented by 3 rising PSA values, each value measured at least 2 weeks apart, with the last measurement being at least 25% of the nadir achieved while on hormonal therapy and with an increase in the absolute value by at least 5 ng/mL

• Measurable disease progression, defined by an increase in the sum of the products of the perpendicular diameters of any measurable lesion(s) by at least 25%

• Bone only progression allowed only with concurrent biochemical progression

• Castrate levels of testosterone (no greater than 50 ng/dL)

• No clinical signs/symptoms suggesting CNS metastases

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-1

Life expectancy

• More than 6 months

Hematopoietic

• WBC at least 3,000/mm^3

• Absolute granulocyte count at least 1,500/mm^3

• Platelet count at least 100,000/mm^3

Hepatic

• Bilirubin no greater than 1.5 times upper limit of normal (ULN)

• AST/ALT no greater than 2.5 times ULN

Renal

• Creatinine no greater than 1.5 times ULN

• Calcium no greater than ULN

Cardiovascular

• No uncontrolled or severe cardiovascular disease

• No myocardial infarction within the past 6 months

• No congestive heart failure

• No angina pectoris

• No active thromboembolic events within the past 3 months (e.g., deep venous thrombosis or cerebrovascular accident)

Other

• No other serious medical or psychiatric illness

• No active infection

• No dementia or significantly altered mental status

• No prior or concurrent grade 1 or greater peripheral neuropathy

• No other prior or concurrent malignancy within the past 5 years except curatively treated nonmelanoma skin cancer

• HIV negative

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Chemotherapy

• No prior chemotherapy (including paclitaxel)

Endocrine therapy

• At least 4 weeks since prior steroids or megestrol

Radiotherapy

• At least 4 weeks since prior radiotherapy to bone lesions

Other

• No other concurrent investigational therapy

Related Conditions & MeSH terms

• Prostate Cancer
• Prostatic Neoplasms

Intervention

Drug:
• bryostatin 1

• paclitaxel

Locations

Country	Name	City	State
United States	Greater Baltimore Medical Center and Cancer Center	Baltimore	Maryland
United States	Fox Chase Cancer Center	Philadelphia	Pennsylvania
United States	Comprehensive Cancer Center at Wake Forest University	Winston-Salem	North Carolina
United States	Wellspan Health - York Cancer Center	York	Pennsylvania

Sponsors (2)

Lead Sponsor	Collaborator
University of Maryland, Baltimore	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States,