Interval Versus Continuous Exercise During Pregnancy

Pregnancy Related Clinical Trial

Official title:

Effects of Acute High-intensity Intervals Versus Moderate-intensity Continuous Cycling on Maternal and Fetal Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05369247
• Other study ID #: Pro00103630
• Status: Completed
• Phase: N/A
• Start date: December 1, 2020
• Est. completion date: December 30, 2022

Study information

• Verified date: October 2022
• Source: University of Alberta
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective of this randomized cross-over design was to investigate the fetal well-being and maternal glycemic response to an acute bout of aerobic high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) with pregnant individuals.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: December 30, 2022
• Est. primary completion date: December 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Carrying a singleton pregnancy (i.e. greater than or equal to 20 weeks of gestation).

• Has access to a stationary bike

• Located within Canada and/or within Edmonton Alberta

Exclusion Criteria:

• History of smoking within the last year

• Taking medications that may interfere with cardiovascular function.

• High-order pregnancies, e.g. twins or above.

• Females with absolute contraindications (as outlined by the Canadian Guidelines for Physical Activity throughout Pregnancy and the PARMed-X questionnaire)

Related Conditions & MeSH terms

• Congenital Abnormalities
• Fetal Heart Rate or Rhythm Abnormality Affecting Fetus
• Glucose, Low Blood
• Pregnancy Related

Intervention

Other:
• High intensity Interval Training
HIIT protocol consisted of 10 one-minute intervals of high-intensity work (i.e., > 90% HRmax) interspersed with nine one-minute intervals of self-paced active recovery (19-minutes total).
• Moderate Intensity Continuous Training
The MICT protocol consisted of 30-minutes of moderate intensity cycling (i.e., 64 - 76% HRmax).

Locations

Country	Name	City	State
Canada	University of Alberta	Edmonton	Alberta

Sponsors (1)

Lead Sponsor	Collaborator
University of Alberta

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Flash Glucose Monitor; interstitial Glucose	Measured by a Flash Glucose monitor inserted onto the back of the left tricep	7-days
Primary	Fetal Heart Rate	Measured via ultrasound pre and post exercise	3-minutes
Primary	Fetal Umbilical Blood Flow	Measured Via ultrasound pre and post exercise	3-minutes
Secondary	Maternal Heart Rate	Measured via heart rate monitor; Measured prior to, during, and after exercise.	40-minutes
Secondary	Accelerometer	The investigators will objectively measure physical activity using an accelerometer for one week. Average number of minutes per day spent in various activity levels will be determined.	7-days
Secondary	Food Log	The investigators will objectively measure nutrients in diet using a seven day food record. This is completed through Food Prodigy/ Food Processor software.	7-days
Secondary	Perceived rating of perceived exertion	Borg Scale; Ratings from 6 - 20; Rating of six is minimal perceived exertion and rating of 20 is maximal perceived exertion.	40-minutes
Secondary	Cardiovascular fitness	Graded exercise test to volitional fatigue.	20-minutes
Secondary	Cerebral Blood Flow of Posterior cerebral artery	Measured using a trans cranial doppler ultrasound. Measured prior to, during, and after exercise.	40-min
Secondary	Sleep Quality	The investigators will objectively measure sleep quality using an accelerometer for one week. Average number of hours of sleep per night, time spent awake after sleep onset, and number of awakenings will be determined	7-days
Secondary	Rating of Perceived Enjoyment (1-10 Scale)	Rating of 1 is the lowest level of perceived enjoyment, rating of 10 is maximal perceived enjoyment	40-minutes
Secondary	Blood pressure	Measured with a finometer; Measured prior to, during, and after exercise.	40-min
Secondary	Cardiac Output	Measured with a finometer; Measured prior to, during, and after exercise.	40-min
Secondary	Cerebral blood flow of middle cerebral artery	Measured using a trans cranial doppler ultrasound. Measured prior to, during, and after exercise.	40-minutes
Secondary	fasted blood sample- sex hormones	Fasted blood samples (~30ml) will be analyzed for sex hormones (estrogen, progesterone, testosterone).	5-minutes
Secondary	Physical Activity Questionnaire	The participants will report physical activity using the pregnancy physical activity questionnaire (gives metabolic equivalent hours per week (MET-hr/week).	5-minutes
Secondary	Depression rating	Participants will answer a 10-question questionnaire regarding their mood. A score of 10 or higher is indicative of depressive symptoms. The investigators will report the over number of women in each group who have a score of 10+ at the start and end of the intervention.	5-minutes
Secondary	Respiratory measures - respiratory frequency	Breathing frequency (breaths per minute). Measured using spirometry.	40-minutes
Secondary	Respiratory measures - tidal volume	Tidal Volume (Liters per breath). Measured using spirometry.	40-minutes
Secondary	Respiratory measures - oxygen	Oxygen metabolism (% oxygen used per breath). Measured using a gas analyzer.	40-minutes
Secondary	Respiratory measures - carbon dioxide	Carbon Dioxide production (% carbon dioxide per breath). Measured using a gas analyzer.	40-minutes
Secondary	Respiratory measures - lung volume	Total Lung Capacity (Liters). Measured using spirometry.	40-minutes
Secondary	Fetal Outcome - birth weight	Participants will provide the investigators with birth weight for the infant (grams)	within one month postpartum
Secondary	fetal outcomes- length	Participants will provide the investigators with birth length for the infant (cm)	within one month postpartum
Secondary	fetal outcomes- gestational age	Participants will provide the investigators with gestational age at delivery (weeks)	within one month postpartum
Secondary	maternal outcomes- mode of delivery	Participants will provide the investigators with mode of delivery (vaginal or cesarean).	within one month postpartum
Secondary	maternal outcomes- delivery complications	Participants will provide the investigators with information regarding any delivery complications.	within one month postpartum
Secondary	maternal outcomes- pregnancy complications	Participants will provide the investigators with information regarding any pregnancy complications (gestational diabetes, pregnancy induced hypertension, preeclampsia).	any time during study
Secondary	fetal outcomes- NICU	Participants will provide the investigators with information regarding length (days) of admission to Neonatal Intensive Care Unit (NICU) if applicable	within one month postpartum
Secondary	maternal outcomes- gestational weight gain	Participants will provide the investigators with the last maternal weight immediately before delivery. This will be used to calculate gestational weight gain (kg; last maternal weight - self reported pre-pregnancy weight).	within one month postpartum