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Congenital Abnormalities clinical trials

View clinical trials related to Congenital Abnormalities.

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NCT ID: NCT04930952 Completed - Venous Malformation Clinical Trials

Complications of Ethanol-amine Oleate Intralesional Sclerotherapy

Start date: February 28, 2019
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to clarify complications of Ethanolamine Oleate intralesional injections of maxillofacial venous formations in pediatric patients

NCT ID: NCT04921722 Recruiting - Clinical trials for Kaposiform Hemangioendothelioma

Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular Anomalies

Start date: June 10, 2021
Phase: Phase 4
Study type: Interventional

In this study, we investigate the safety and efficacy of topical sirolimus in the treatment of superficial complicated vascular anomolies.

NCT ID: NCT04912674 Not yet recruiting - Cervical Deformity Clinical Trials

Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity

Symphony
Start date: June 1, 2021
Phase:
Study type: Observational

Multi-center, prospective, non-randomized study to evaluate Symphony™ Posterior Cervical System in the setting of surgical treatment of adult cervical deformity.

NCT ID: NCT04911686 Not yet recruiting - Clinical trials for Flexion Deformity of Knee

Correction of Fixed Knee Flexion Deformity in Children Distraction by Cast Wedge and Rod Lengthening

Start date: June 1, 2021
Phase:
Study type: Observational

The aim of our study is to produce gradual correction of FKFD in younger children.

NCT ID: NCT04910074 Not yet recruiting - Nerve Injury Clinical Trials

LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery

Start date: July 2021
Phase: N/A
Study type: Interventional

Low-level laser therapy (LLLT) is a well-studied technique that has been shown to improve recovery time and reduce pain and swelling in patients undergoing surgery, including orthognathic surgery, and has no known negative effects. This study will use two groups with patients randomly assigned to either the study group, receiving LLLT, or one receiving a placebo treatment, after they have lower jaw surgery. Measurements will be taken at 24 hours, 1 week, 2 week, 3 week, 4 week, 5 week, and 6 week post-op exams to check pain, swelling and nerve function, and the two groups will be compared to see if the LLLT group has any difference

NCT ID: NCT04901819 Recruiting - Clinical trials for Anorectal Malformations

Longterm Outcomes of Individuals With Anorectal Malformations

Start date: June 1, 2021
Phase:
Study type: Observational

This is a cross-sectional observational study with the aim to assess longterm outcomes in a large cohort of individuals with anorectal malformations. Patients managed for anorectal malformations at Karolinska University Hospital, Stockholm, Sweden, Stockholm 1994-2017 will be reviewed and they will be invited to respond to validated questionnaires evaluating bowel function (>4 years of age), urinary tract function (>4 years of age), sexual function (>18 years of age) and quality of life (>8 years of age). Data will be analyzed with descriptive and comparative statistics.

NCT ID: NCT04899297 Recruiting - Quality of Life Clinical Trials

Quality of Life in Parents of Adolescents With Spinal Deformities: Development of a New Questionnaire.

Start date: May 7, 2021
Phase:
Study type: Observational

This study aims to develop a new instrument capable of providing an efficient measure of the quality of life of parents of conservatively treated patients with spinal deformity. The development of a questionnaire in a Rasch environment and specifically developed for parents of conservatively treated patients will ensure greater sensitivity and specificity of the questionnaire.

NCT ID: NCT04897178 Not yet recruiting - Fetal Anomaly Clinical Trials

Machine Learning-based Anomaly Recognition System

MARS
Start date: June 1, 2021
Phase:
Study type: Observational

MARS is an artificial intelligence-powered system that aims at detecting common fetal anomalies during real-time obstetrics ultrasound. The current study comprises 2 stages: (1) The stage of model creation which will include retrospective collection of images from fetal anatomy scans with known diagnoses to train these model and test their diagnostic accuracy. (2) The stage of model validation through prospective application of this model to collected videos with known normal and abnormal diagnoses

NCT ID: NCT04888377 Not yet recruiting - Clinical trials for Neurodevelopmental Abnormality

ASPIRIN: Neurodevelopmental Follow-up Trial

Start date: September 2021
Phase:
Study type: Observational

A total of 620 children will be enrolled in this study from six sites in sub-Saharan Africa, South Asia, and Latin America. Half of the children's mothers will have taken aspirin and half will have taken placebo. This will allow the researchers to compare results of the two groups of children and determine if children exposed antenatally to low dose aspirin will have scores on the Bayley Scales of Infant Development-III (BSID-III) examination at 36 months of life (+/-3months) that are not inferior to the child's peers who were not exposed (i.e., by no more than a margin of 4 points).

NCT ID: NCT04885387 Completed - Pectus Deformity Clinical Trials

X-ray-free Protocol for Pectus Deformities Based on Magnetic Resonance 1 Imaging and a Low-cost Portable Three-dimensional Scanning Device

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

Pectus excavatum (PE) and pectus carinatum (PC) are the most frequent chest wall deformities in humans. They are usually clinically recognized in early childhood or adolescence, with aggravation during the pubertal growth spurt. PE is a depression of the anterior chest wall, most frequently involving the lower sternum. In this study we use simultaneously compared chest CT, MRI, and 3D scanning fro both PE and PC assessment . The aim of this study is to compare a standard protocol using chest CT to a non-irradiant protocol with 3D scanning and MRI. The primary endpoint was to assess the inter observer concordance and the correlation between the HI (Haller Index) evaluated with MRI and the EHI (External Haller index) evaluated with 3D scanning. The secondary endpoints were to assess the concordance with chest CT the variation of the HI evaluated in inspiration and expiration with MRI and also the correction index (CI) between chest CT and MRI in the PE group, .