Preeclampsia Clinical Trial
Official title:
Leptin and Cytokines in Diabetic Pregnancy - Physiologic or Pathogenic Role
Leptin, a circulating hormone expressed abundantly in adipose tissue, has been reported to
be a satiety factor. In addition, it has been shown to increase during pregnancy in maternal
blood, parallel to increase in body fat mass, to correlate with fetal body weight gain and
to fall down to basal levels after delivery.
Little is known about leptin levels in pregnant women with preexisting or gestational
diabetes and their relationship with fetal and postnatal growth and perinatal complications.
Therefore, the proposed study aims to understand and characterize the role of leptin in
gestational diabetes mellitus as well as the relationship between leptin, cytokines and the
pathophysiological complications during diabetic pregnancy. Specifically, we will evaluate
60 pregnant women both in Germany and in Israel and evaluate serum levels and mRNA of
leptin, cytokines (inflammatory as well as Th1 and Th2) and correlate them to maternal
changes of body weight and birth weight in women of various degrees of glucose tolerance and
with various degrees of metabolic control during pregnancy; relationship between serum and
umbilical cord vein concentrations of leptin, cytokines and metabolic variables; placental
expression of leptin, leptin receptor, selected cytokines, GLUT1 and 4 and relationship to
leptin in serum and umbilical cord plasma; comparison between all above parameters of German
and Israeli pregnant women.
The results of this new and systematic study will shed light on the role of leptin and
cytokines in the development of glucose disturbances during pregnancy and the perinatal
outcome of women with gestational or preexisting diabetes mellitus.
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