Inflammation Clinical Trial
Official title:
Acute Effect of Oleocanthal Rich Extra-virgin Olive Oil on Postpranial Hyperglycemia and Platelet Activation of T2DM Patients
This is a pilot acute dietary intervention study with a randomized cross-over design aiming
to investigate whether acute supplementation of extra virgin olive oil (EVOO) rich in
oleocanthal could attenuate postprandial hyperglycemia and activation of platelets in T2DM
patients. For this reason, non-insulin dependent diabetic patients (10-15) will be randomly
assigned to consume in five different days white bread (50 g CHO) with butter, butter with
ibuprofen, refined olive oil and olive oil with oleocanthal (250 mg/Kg 500 mg/Kg). Blood
samples will be collected pre- and post-intervention up to 4 hours in order to determine
platelet aggregation, postprnadial glycemia, lipemia, inflammation and oxidative stress.
Taking into account the strong anti-inflammatory and anti-platelet properties of oleocanthal,
this study will assess whether oleocanthal-rich olive oils could exert similar effects under
real in vivo conditions in T2DM patients. It will also assess whether these effects are
achieved through improvement of postprandial glycemia and lipemia.
n/a
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