Correlation of Platelets Count With Endoscopic Findings in a Cohort of

Status Recruiting

Clinical Trial Summary

Portal hypertension is a common complication of liver cirrhosis that can lead to development of esophageal varices (EV). They are abnormally dilated veins within the wall of the esophagus that lead to haemorrhage (1). Majority of patients with cirrhosis will develop EV at some point, and about third of these patients will have at least one bleeding episode because of rupture of a varix . For this reason, screening endoscopy for detection of the presence of EV should be part of the diagnostic work-up in patients with cirrhosis. This is a very important preventive step for identification of those patients with variceal bleeding risk and furthermore, identification of patients in urgent need for prophylactic treatment.

All guidelines stress on screening endoscopy for early detection of EV in cirrhotic patients with portal hypertension. However this approach is limited by its invasiveness and cost effectiveness issues of screening endoscopy .

Clinical Trial Description

Recent research has focused on the use of noninvasive methods to detect patients with the intention of avoiding endoscopy in low-risk cases . Thrombocytopenia (platelet count < 150,000/μl) is a common complication in patients of chronic liver disease (CLD) . So, the investigators in this research formulated this study to determine whether platelet count can predict the presence of EV or varices which need prophylactic therapy (medium or large size EV) in a cohort of Egyptian patients with liver cirrhosis and can identify patients with the intention of avoiding endoscopy in low-risk cases. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02621372
Study type	Observational
Source	Tanta University
Contact	Sherief M Abd-Elsalam, lecturer
Phone	00201095159522
Email	sherif_tropical@yahoo.com
Status	Recruiting
Phase	N/A
Start date	January 2015
Completion date	October 2019

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Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms