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Polyphenols clinical trials

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NCT ID: NCT06020313 Recruiting - Clinical trials for Cardiovascular Diseases

Autonomic and Cardiovascular Recovery After the Acute Use of Resveratrol in Overweight and Obesity Individuals

Resveratrol
Start date: August 2023
Phase: N/A
Study type: Interventional

The aim of this study is to understand the importance of resveratrol supplementation as a possible adjuvant in improving the metabolic profile and cardiovascular autonomic recovery of individuals with overweight and grade I obesity, reducing the incidence of diseases associated with obesity and the costs in primary, secondary and tertiary care.

NCT ID: NCT05773794 Completed - Polyphenols Clinical Trials

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

Start date: February 6, 2023
Phase: N/A
Study type: Interventional

This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.

NCT ID: NCT05488886 Completed - Metabolism Clinical Trials

Bioavailability of Aronia Berry Polyphenols

Start date: February 9, 2023
Phase: N/A
Study type: Interventional

The objective of this study is to conduct a randomized cross-over dietary intervention among healthy adults to compare the bioavailability and the fecal polyphenol metabolites of intervention foods made with whole aronia berry powder, aronia berry extract, phospholipid-polyphenol (PLP), and a low-polyphenol control. 10 participants will be enrolled and can expect to be on study for up to 28 days.

NCT ID: NCT04335435 Completed - Pharmacokinetics Clinical Trials

Avenanthramide and Saponin Bioavailability in Oat Bran

Start date: January 15, 2016
Phase: N/A
Study type: Interventional

Avenanthramides and saponins are types of chemical compounds found naturally in oats. Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and anti-proliferative effects on cancer cells in vitro. Oat saponins, or avenacosides, have the ability to bind cholesterol, and thus, the ability to lower blood cholesterol. Oat bran is a known source of these dietary compounds. This study aims to determine the bioavailability of these compounds to in the urine of participants after ingesting an oat bran cereal, both before, and after for multiple time points. Analytical chemistry will be used to determine the bioavailability of the oat compounds at each time point. This will help to establish a kinetic curve for the metabolism of these compounds.

NCT ID: NCT03990181 Completed - Iron Overload Clinical Trials

Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement

Start date: September 20, 2019
Phase: N/A
Study type: Interventional

Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic mutation in the regulatory pathway, leading to excess iron in the body. This study investigates the inhibitory effect of a natural polyphenol Supplement in participants with HH.

NCT ID: NCT03911050 Completed - Pharmacokinetics Clinical Trials

Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human

Start date: November 26, 2018
Phase: N/A
Study type: Interventional

This is an interventional study to investigate formation and pharmacokinetics of reactive carbonyl species adducts of apple polyphenols in human after a single dose of apple consumption.

NCT ID: NCT03453918 Completed - Iron Absorption Clinical Trials

Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.

POLYFER
Start date: April 9, 2018
Phase: N/A
Study type: Interventional

Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators. Investigator hypothesize that polyphenol supplementation can reduce iron absorption in iron overload disease. Iron absorption can be studied by the area-under-the-curve of serum iron after iron oral loading. The primary outcome is the decrease of post-prandial serum iron after rich-iron meal, due to polyphenol supplementation.

NCT ID: NCT03444155 Completed - Healthy Clinical Trials

Natural Versus Synthetic Vitamin B Complexes in Human

Start date: May 8, 2017
Phase: N/A
Study type: Interventional

In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) (Pan [Greek] = all; moles [Latin] = molecules/particles - brand name) versus synthetic vitamin B complexes to identify the bioavailability of distinct vitamins as well as long-term effects. The primary hypothesis for this study: "Natural Vitamin B-complexes are as effective as synthetic Vitamin B-complexes or better." For this reason 30 subjects (18 to 65y; BMI >19 to <29) were recruited for this study. The study population was divided into 2 groups of each 15 subjects in a cross-over trial. Vitamin supplementation consisted of Thiamine (2.93 mg), Riboflavin (3.98 mg), Niacin (29.85 mg), Pantothenic acid (10.95 mg), Pyridoxine (3.38 mg), Biotin (0.108 mg), Folic acid (0.69 mg) and Cobalamin (8.85 µg) per day in both groups. Blood samples are taken at baseline - 1.5h after vitamin supplementation - 4h - 7h - 6 weeks - wash out phase I (2 weeks); start cross-over: baseline - 1.5h after vitamin supplementation - 4h - 7h - 6 weeks - washout phase II (6 weeks). In case of main target criteria Thiamin, Riboflavin, Pyridoxine, Folic acid and Cobalamin were measured in serum as well as total peroxides (µmol/L), peroxidase-activity (U/L), total antioxidant status (mmol/L) and polyphenols (mmol/L).

NCT ID: NCT03419052 Completed - Cognition Clinical Trials

MINDSpeed Food and Brain Training RCT

MINDSpeed
Start date: January 10, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance

NCT ID: NCT02209103 Completed - Fatigue Clinical Trials

The Sleep Improving Effects of Orange Phenolics

Start date: March 2014
Phase: N/A
Study type: Interventional

This study aims to determine whether a citrus flavonoid or a citrus flavonoid formulation can improve objective sleep duration and/or quality, and/or improve perceived sleep quality and feelings of rest. Participants will complete a total of 9 test nights, which consist of sleeping with the sleep monitoring system after ingestion of the test product or a placebo, and filling out sleep-related questionnaires. The study has a crossover design, meaning that all participants receive all three interventions (citrus flavonoid, citrus flavonoid formulation, placebo) three times, in a randomized order.