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Polycystic Ovary Syndrome clinical trials

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NCT ID: NCT05084274 Terminated - Infertility, Female Clinical Trials

Optimising Preconceptual Health in Subfertile PCOS Patients Using a Lifestyle Modification Program

Start date: September 10, 2021
Phase: N/A
Study type: Interventional

Patients will be randomly assigned to a group where they undergo a 12-week lifestyle modification program prior to their fertility treatment, or a group where they are entitled to start their fertility treatment without prior lifestyle modification program.

NCT ID: NCT04327934 Terminated - Hypertension Clinical Trials

Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome

Start date: December 1, 2017
Phase: Early Phase 1
Study type: Interventional

Women with androgen excess polycystic ovary syndrome (AE-PCOS) leads to hypertension.

NCT ID: NCT04306692 Terminated - Clinical trials for Polycystic Ovary Syndrome

Myo-inositol Versus Clomiphene Citrate in PCOS

Start date: July 2, 2020
Phase: Phase 4
Study type: Interventional

Specific aim: To compare inositol and the golden standard first line treatment of ovulation induction, namely clomiphene citrate.

NCT ID: NCT03380091 Terminated - Depression Clinical Trials

Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial

MINDD
Start date: December 12, 2017
Phase: Phase 4
Study type: Interventional

Open-label randomized clinical trial assessing the efficacy of Metformin versus Vitamin D in improving symptoms of depressed mood in polycystic ovary syndrome.

NCT ID: NCT03119077 Terminated - Clinical trials for Polycystic Ovary Syndrome

Single Ascending Dose, First-in-Human Study on Safety, Tolerability and Pharmacokinetics of BAY1161116

Start date: April 27, 2017
Phase: Phase 1
Study type: Interventional

This study will be conducted in a single center, double-blind with 6 dose escalation groups to evaluate the safety, tolerability, and pharmacokinetics of single ascending doses of BAY1161116.

NCT ID: NCT02865915 Terminated - Clinical trials for Polycystic Ovary Syndrome (PCOS)

MLE4901 vs. Placebo for the Treatment of PCOS

Start date: July 2016
Phase: Phase 2
Study type: Interventional

This is a Phase 2b double-blind, randomized, parallel-group, placebo-controlled study of MLE4901 versus placebo in women with PCOS.

NCT ID: NCT02785822 Terminated - Clinical trials for Polycystic Ovary Syndrome

Study to Compare hFSH-HP (Fostipur) and hMG-HP(Meriofert) in Patients With Polycystic Ovary Under a IVF/ICSI Cycle.

Start date: February 23, 2017
Phase: Phase 4
Study type: Interventional

Polycystic ovary occurs in 15-20% of the population will be submitted to TRA. Whether it is associated with other signs or symptoms (polycystic ovarian syndrome) as if presented in isolation, its therapeutic management has special connotations sometimes favoring the low response although the standard is the tendency to hyperresponsiveness. Although there are studies comparing the combination of FSH and LH and FSH in controlled hyperstimulation of these patients, there are no previous prospective randomized studies comparing administration of urinary FSH (hFSH-HP) with a combination of FSH and HCG (HMG HP). Therefore the aim of this study is to prove that both drugs are comparable in the treatment of these patients. The test substances are marketed in Spain (Fostipur and Meriofert, respectively) with an indication for use in these patients. In this study both medicines will be administered in a randomized way under the usual conditions in which it is used in routine clinical practice to compare the quantity of mature oocytes respect to the total oocytes obtained, as a primary outcome measure.

NCT ID: NCT02523898 Terminated - Clinical trials for Polycystic Ovary Syndrome

Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant

Start date: November 2015
Phase: Phase 2
Study type: Interventional

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility which affects 12-21% of the population.Several studies performed evaluate the possible benefit of metformin alone or in combination with clomiphene (CC)as first-line treatment for infertility in women with PCOS have reported conflicting results. These conflicting results may be due to the presence or absence of insulin resistance(IR).Metformin decreases IR .However there is not a single randomized clinical trial with metformin in IR PCOS patients. Therefore, the aim of current study is to compare CC with coadministration of metformin and with CC with coadministration of placebo in IR PCOS patients to induce ovulation.

NCT ID: NCT02221154 Terminated - Clinical trials for Polycystic Ovary Syndrome

Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)

FIV-INOPK
Start date: November 2014
Phase: Phase 4
Study type: Interventional

The original mechanism of action of myo-inositol and preliminary results available in the literature on its use in IVF suggest its value as adjuvant gonadotropin therapy to reduce the risk of OHSS in PCOS patients. The aim of the study is to demonstrate that administration of myo-inositol decreases the incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk infertile with PCOS supported in IVF patients.

NCT ID: NCT02052479 Terminated - Clinical trials for Polycystic Ovary Syndrome

Insulin Differences Between African-American and Caucasian Female Adolescents With Polycystic Ovary Syndrome (PCOS)

Start date: January 2014
Phase: N/A
Study type: Interventional

The purpose of this research study is to see if there are differences between African-American and Caucasian girls with Polycystic Ovary Syndrome (PCOS) in how their bodies respond to a type of sugar, called glucose, the body's main source of energy. PCOS is one of the most common endocrine disorders among females. Features can include anovulation (eggs are not released from the ovaries) resulting in irregular menstrual periods, excessive amounts of androgenic (male) hormones resulting in acne and hirsutism (excessive hair growth on the face and body), and polycystic ovaries (small sac-like structures [cysts] on your ovaries) seen on ultrasound. Girls with PCOS also have higher levels of insulin in their bodies (called hyperinsulinism) but are not able to use insulin very well (called insulin resistance) resulting in an increased risk of diabetes. Diabetes is when you have high levels of glucose (sugar) in your blood. Many studies have looked at how bodies respond to glucose and have shown that compared to Caucasians, healthy African-Americans produce much more insulin (hyperinsulinism) but are not able to use it as well (insulin resistance) in childhood, adolescence, and adulthood. Insulin is a hormone that helps glucose move from the blood into the muscles for the body to use as energy. PCOS is associated with increased levels of insulin (hyperinsulinism) and not being able to use it as well (insulin resistance). So we want to see if there is a difference in insulin production (secretion) and insulin resistance between African-Americans and Caucasians girls with PCOS. To do this, we will look at blood glucose and insulin levels in response to giving glucose in African-American and Caucasian girls who have PCOS. The results of this study may ultimately help to more effectively target treatment therapy in individuals with PCOS that have increased insulin secretion and/or increased insulin resistance.