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Phantom Limb clinical trials

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NCT ID: NCT06428123 Active, not recruiting - Phantom Limb Pain Clinical Trials

Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in AKAP

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

Limb amputation results in many types of pain, including localized pain at the stump and projected pain experienced by the patient in the location where the amputated limb used to be, known as phantom limb pain (PLP). The aim of this study is to determine the relative benefits of mirror therapy vs mental imagery in reduction of phantom limb pain. Randomized clinical trial study design will be followed.

NCT ID: NCT06262503 Active, not recruiting - Clinical trials for Phantom Pain Following Amputation of Lower Limb

the Influence of Virtual Reality Approach on Phantom Pain in Trans Tibial Amputation

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

1. To investigate the effect of Virtual reality (VR) on phantom limb pain in trans tibial amputation. 2. To investigate the effect of Virtual reality (VR) on lower limb Function in trans tibial amputation. A sample size of 60 will be randomly allocated to two groups(30 in each group) , by using computer-generated random number list method. Control group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) for reducing phantom pain in trans -tibial amputation and the experimental group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) and Virtual Reality for reducing phantom pain in trans -tibial amputation .

NCT ID: NCT05915065 Active, not recruiting - Amputation Clinical Trials

VR to Evaluate Phantom Limb Pain

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to develop a virtual rehabilitation system that can be used to effectively treat Phantom Limb Pain (PLP) within the research setting and for at-home use by individuals with upper and lower extremity amputation. We hypothesize that the system will improve PLP for individuals with upper or lower extremity amputation, as measured through with various outcome measures and questionnaires.

NCT ID: NCT03029884 Active, not recruiting - Chronic Pain Clinical Trials

Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain

Start date: October 28, 2017
Phase: N/A
Study type: Interventional

Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief. A "one-size-fits-all" approach of continuous, 24/7 brain stimulation has helped patients with some movement disorders, but the key to reducing pain may be the activation of stimulation only when needed, as this may help keep the brain from adapting to stimulation effects. By expanding the technological capabilities of an investigative brain stimulation device, the investigators will enable the delivery of stimulation only when pain signals in the brain are high, and then test whether this more personalized stimulation leads to reliable symptom relief for chronic pain patients over extended periods of time.

NCT ID: NCT02519907 Active, not recruiting - Phantom Limb Pain Clinical Trials

Surface Electrical Stimulation for Treatment of Phantom Limb Pain

EPIONE
Start date: September 2015
Phase: N/A
Study type: Interventional

Phantom limb pain (PLP) is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours in cases where the loss of the limb is required for the survival of the patient. The loss of a limb or other body parts is usually followed by the sensation that the lost body part is still present and can be felt. These phenomena are called, respectively, phantom awareness and phantom sensation. In 50-80% of amputees neuropathic pain develops in the lost limb also referred to as phantom limb pain (PLP). PLP can be related to a certain position or movement of the phantom limb, and might be elicited or worsened by a range of physical factors (e.g. changes in the weather or pressure on the residual limb) and psychological factors (e.g. emotional stress). It is well known that most treatments available for PLP today, such as pharmacological, surgical, anaesthetic, psychological and other, are ineffective. Today it is believed that phantom limb pain may be related to changes in the cortex of the brain. There is evidence that these changes may be modulated - or even reversed - by providing sensory input to the stump or amputation zone. For example, cortical reorganization and alleviation of phantom limb pain has been observed in amputees following intense use of a hand prosthesis. However, there is no consistent knowledge on which type of peripheral sensory feedback may be effective in affecting the cortical plasticity or on how to best apply the sensory feedback. The aim of the proposed research is to create natural, meaningful sensations through providing non-invasive sensory feedback (i.e. surface electrical stimulation) and the effectiveness to alleviate phantom limb pain and restore the cortical neuroplastic changes.

NCT ID: NCT02487966 Active, not recruiting - Phantom Limb Pain Clinical Trials

Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS)

Start date: July 2015
Phase: N/A
Study type: Interventional

This is a two-site study that explores the effects of mirror therapy and transcranial Direct Current Stimulation (tDCS, Soterix ©) in a randomized factorial controlled trial in which patients will be assigned to one of four groups: active tDCS and active MT; sham tDCS and active MT; active tDCS and sham MT (which consists of using a covered mirror for the therapy); and both sham tDCS and sham MT (covered mirror).

NCT ID: NCT02221934 Active, not recruiting - Phantom Limb Pain Clinical Trials

Electrical Nerve Block for Amputation Pain

Start date: October 9, 2014
Phase: N/A
Study type: Interventional

The purpose of the clinical trial is to learn whether electrical nerve block via the Altius System is a safe and effective treatment for patients with post-amputation pain.

NCT ID: NCT01554332 Active, not recruiting - Neuropathic Pain Clinical Trials

Motor Cortex Stimulation for Chronic Neuropathic Pain

Start date: October 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy of cortical stimulation (CS) as an adjunctive treatment for chronic neuropathic pain.

NCT ID: NCT01462448 Active, not recruiting - Phantom Limb Clinical Trials

Study to Identify the Genetic Variations Associated With Phantom Limb Pain

Start date: March 2012
Phase:
Study type: Observational

The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.