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Periodontitis clinical trials

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NCT ID: NCT05786820 Recruiting - Periodontitis Clinical Trials

Impact of Pycnogenol® on Gingival Inflammation

PINEGIN
Start date: March 17, 2022
Phase: N/A
Study type: Interventional

This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract (Pycnogenol®) on clinical signs of gingival inflammation in a cohort of periodontal aftercare patients

NCT ID: NCT05783011 Completed - Periodontitis Clinical Trials

The Effects of Electroacupuncture on Postoperative Pain

Start date: March 30, 2021
Phase: N/A
Study type: Interventional

In this study,the investigators aimed to examine the effect of electroacupuncture application on the amount of pain felt by patients after periodontal surgery. The main question it aims to answer is there any efficiacy of electroacupuncture application on postoperative pain reduction. Participants will get periodontal flap surgery treatment with/without electroacupuncture Researchers will compare EA and control groups to see if there is any relationship between acupuncture application and postoperative pain

NCT ID: NCT05778227 Completed - Clinical trials for Apical Periodontitis

Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.

Start date: November 16, 2021
Phase: N/A
Study type: Interventional

The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral canals. Instrumentation alone cannot reach all the areas for cleaning.The objectives of this research study is to observe and compare the effect of irrigation with smearOFF , etidronic acid/ hypochlorite and other irrigants on sealer penetration and dentin erosion of root dentin by using scanning electron microscope (SEM) and Energy Dispersive X-Ray Analysis (EDX). Hundred extracted premolar teeth is subjected to root canal instrumentation. The endodontic procedure is done with protaper gold files. Initial irrigation is done by 5% sodium hypochlorite. Samples are divided into five groups. Each group consists of twenty single rooted premolars based on final irrigation regimen. There will be four experimental groups which are as follows (1) 17% EDTA (2) SmearOFF 3) Maleic acid (4) HEBP/NaOCL. Whereas, saline will be the control group. After the preparation and final irrigation of all teeth with experimental irrigants, sterile saline is used to flush all canals and dried using paper points. After final irrigation teeth are further divided into two groups (A) Sealer penetration (B) Dentin erosion. In both the groups standardization of root length, cleaning and shaping procedure are the same. For sealer penetration, obturation is done by warm vertical using AH plus sealer. Samples are incubated at 37º Celsius (°C) and 100% humidity for 7 days. The samples are marked and divided into three horizontal section at 2mm, 5mm and 8mm. Using SEM, measure the maximum depth of sealer penetration on each side that is buccal, lingual, mesial and distal and take the mean for each section of sample. For dentin erosion (B) samples are divided sagitally & buccolingually into two halves. The half containing the most visible part of apical area is taken and than examined using EDX. One-Way ANOVA-test will be used to compare mean values of multiple groups. Tukey's post hoc test will be used to determine the group with significance at P≤0.05. Two observers will evaluate the results using kappa statistics.

NCT ID: NCT05773911 Recruiting - Periodontitis Clinical Trials

Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel

Chitosangel
Start date: March 23, 2023
Phase: N/A
Study type: Interventional

In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a more conventional treatment strategy, with the aim to hinder the progression of bone loss around the teeth.

NCT ID: NCT05770258 Completed - Periodontitis Clinical Trials

The Novel Electrolyzed Water Spray Treatment Mild Periodontitis

Start date: January 29, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to test whether spraying the tooth of patients by use of the novel electrolyzed water spray will produce improvement in the condition of mild periodontitis.

NCT ID: NCT05768243 Completed - Clinical trials for Periodontitis Chronic Generalized Severe

Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis

Start date: March 1, 2021
Phase: Phase 4
Study type: Interventional

the aim of this clinical trial is to compare the efficacy of hyaluronic acid (HA) used as an adjunctive to scaling and root planing (SRP) and red injectable platelet rich-fibrin (i-PRF) in the non-surgical treatment of stage III periodontitis. The main question it aims to answer is: is there a difference between HA and red i-prf when used as an adjunct to SRP in terms of efficacy? Participants who are eligible will be assigned to one of the treatment groups: - Group 1= receives HA+ SRP - Group 2= receives red i-prf + SRP - Group 3= receives only SRP Researchers will compare Groups 1,2 and 3 to see if there's a difference in the periodontal parameters measured.

NCT ID: NCT05765513 Completed - Periodontitis Clinical Trials

HA35 Treatment the Gingival Discomfort as Well as Gingival Redness and Bleeding of Patients With Periodontitis

Start date: February 2, 2023
Phase: N/A
Study type: Interventional

The main objective of this study is to research the treatment of 35 kDa hyaluronan fragment HA35 for Mild periodontitis and associated with gingival discomfort or itchiness.

NCT ID: NCT05763420 Enrolling by invitation - Clinical trials for Root Canal Infection

Clinical Efficacy of AH Plus Bioceramic Sealer

Start date: August 7, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to assess the efficacy and outcome of sealer-based obturation (SBO) using a new calcium silicate sealer in comparison with warm vertical compaction (WVC) using a resin-based sealer, which is the current gold standard.

NCT ID: NCT05759416 Completed - Clinical trials for Chronic Periodontitis

Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis

Start date: April 1, 2020
Phase: Phase 4
Study type: Interventional

This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.

NCT ID: NCT05757921 Completed - Periodontitis Clinical Trials

Comparison of Adjunctive Chemomechanical Therapy With Standard Care in Patients With Periodontitis

Start date: October 24, 2011
Phase: N/A
Study type: Interventional

The goal of the clinical trial is to compare adjunctive chemomechanical therapy with standard care regarding root planning in patients with periodontitis. The primary outcome is to measure pocket depth before and after treatment in the test, and control group respectively Secondary outcomes: - Bleeding on probing - Plaque index - Quality of life from standardized protocol The hypothesis is that non- surgical mechanical treatment with chloramines in patients with periodontitis will show a better pocket closure after the treatment.