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Periodontitis clinical trials

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NCT ID: NCT02568163 Terminated - Clinical trials for Chronic Periodontitis

Influence of Stress on Non Surgical Periodontal Treatment

Start date: September 2013
Phase: N/A
Study type: Interventional

Treatment of periodontal diseases is influenced by several risk factors. Psychological stress is considered as one of them. Aim of this study is to assess if stress influences results of non surgical periodontal treatment in severe chronic forms of periodontitis.

NCT ID: NCT02441920 Terminated - Clinical trials for Rheumatoid Arthritis

Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid Arthritis

Start date: November 2010
Phase:
Study type: Observational

Periodontitis is a highly prevalent chronic inflammatory disease that is characterized by loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss. Results from clinical and epidemiological studies have suggested that periodontitis and tooth loss are more prevalent in individuals with rheumatoid arthritis (RA). There is evidence to suggest that periodontitis could indeed be a causal factor in the initiation and maintenance of the autoimmune inflammatory response that occurs in RA. If so, chronic periodontitis might represent an important modifiable risk factor for RA. However, to date longitudinal studies on the effect of periodontitis on disease progression in RA are lacking. The aim of the present study is to assess the periodontal status of patients enrolled in an established longitudinal cohort of RA patients. These data will then be analysed to evaluate whether or not periodontal inflammation is related to parameters of rheumatoid arthritis.

NCT ID: NCT02394860 Terminated - Hypertension Clinical Trials

Influence of Periodontal Diseases on Vascular Parameters in Patients Suffering of Hypertension

Start date: April 2015
Phase:
Study type: Observational

The aim of this study is to assess the influence of the severity of chronic periodontitis on hemodynamic parameters in hypertensive patients.Secondary purposes of this protocol is to identify evolution of several biomarkers and correlate the clinical situation with oral microflora.

NCT ID: NCT02316652 Terminated - Clinical trials for Chronic Periodontitis

Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

Start date: January 15, 2014
Phase: N/A
Study type: Interventional

This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD), reducing bleeding on probing (BOP), and gaining clinical attachment level (CAL). It also will assess whether chemical pocket disinfection with scaling and root planing will have an effect on biomarkers of inflammation.

NCT ID: NCT02214095 Terminated - Clinical trials for Chronic Periodontitis

Glucosamine Periodontal Adjunctive Therapy

Start date: January 2012
Phase: Phase 0
Study type: Interventional

This study is the first evidence based work evaluated the systemic use of glucosamine as an adjunctive therapy to closed mechanical debridement in chronic periodontitis. The use of glucosamine sulphate was correlated with clinical outcomes and IL1-β level in the GCF of patients with moderate to advanced chronic periodontitis

NCT ID: NCT01993368 Terminated - Clinical trials for Chronic Periodontitis

Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis

PAG
Start date: November 2013
Phase: N/A
Study type: Interventional

Periodontitis are inflammatory diseases characterized by the destruction of the tooth-supporting bone due to increased bone resorption by osteoclasts (OCLs). Two forms are described: chronic periodontitis (CP) and aggressive periodontitis (AP) that differ by the severity and rapidity of bone loss, much more important for AP than CP. In both forms, the link with uncontrolled activation of the immune system is largely admitted. Despite the physiopathology of CP is fairly well studied, very few data are available regarding AP. The investigators aim is to understand the severity of AP by analyzing the proportion and action of immune and mesnchymal cells potentially involved in bone destruction, on biopsies of periodontal granulation tissue (surgical waste) and blood. Three groups of 20 patients will be included: affected with AP, CP or controls (necessitating an extraction of wisdom teeth).

NCT ID: NCT01878864 Terminated - Periodontitis Clinical Trials

Effect of Local Anesthesia in Patients With Marginal Periodontitis Undergoing Scaling and Root Planning

Start date: November 2012
Phase: Phase 2
Study type: Interventional

A randomised cross-over study comparing two methods of local anaesthesia for patients diagnosed with periodontitis undergoing scaling and root planning. 40 patients will be included in the study, which aims to demonstrate that the effect of a bupivacaine lozenge is non-inferior to lidocaine-adrenalin injections.

NCT ID: NCT01806974 Terminated - Clinical trials for Rheumatoid Arthritis

Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium

ParoPAR
Start date: December 2012
Phase: Phase 4
Study type: Interventional

Rheumatoid arthritis and periodontitis are two inflammatory diseases that share many pathophysiological similarities as some inflammatory mediators like TNF-alpha, IL-1, Il-6, Il-17, Il-12 et Il-17, RANK-L, or OPG The most severe or progressive forms of rheumatoid arthritis require in 10-30% of cases, the use of biotherapies such as anti-TNF-alpha, anti CD-20 and anti-lL-6. All these treatments results in, among other things, an increased risk of infection, both viral and bacterial. These new biotherapies could have an impact on periodontal status - either by favouring sub gingival colonization of root surfaces by periodontal pathogenic bacteria and initiate periodontitis or exacerbate pre-existing periodontitis, - or a positive modulation of the host response by inhibiting bone resorption of the alveolar process. To date, very few studies have been conducted on this subject which is really a translational research, involving several medical specialties.

NCT ID: NCT01030666 Terminated - Periodontitis Clinical Trials

Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy

GTRDOXY
Start date: April 2007
Phase: Phase 4
Study type: Interventional

Study Hypothesis: The administration of 200 mg doxycycline once a day for 7 days after regenerative periodontal therapy of infrabony defects improves the results of therapy (clinical vertical attachment gains [CAL-V], bony fill) and reduces postoperative flap dehiscence and defect exposure. In each of 90 patients one infrabony defect shall be treated by regenerative techniques (guided tissue regeneration [GTR], enamel matrix derivative [EMD]). Prior to , 6, 12, and 24 months after surgery clinical measurements (Plaque Index [PlI], probing depth [PD], vertical clinical attachment level [CAL-V], Gingival Index [GI]) and standardized radiographs are obtained.

NCT ID: NCT00906776 Terminated - Periodontitis Clinical Trials

Emdogain and Straumann Bone Ceramic in Infrabony Defects

Start date: April 2007
Phase: N/A
Study type: Interventional

To compare the clinical effect of the combination of bone ceramic and enamel matrix proteins (test) versus autogenous bone graft alone (control) in the treatment of deep-wide intrabony defects