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Periodontitis clinical trials

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NCT ID: NCT04478643 Recruiting - Clinical trials for Periodontal Diseases

Lactobacillus Reuteri in the Supportive Therapy of Periodontitis

PERIOPRO
Start date: October 7, 2020
Phase: N/A
Study type: Interventional

Literature shows the potential effectiveness of L. reuteri as an adjunct to non-surgical periodontal therapy in initial treatment of periodontitis, but also underlines the limits of the conclusions, and the heterogeneity and limited sample size of the available studies. Therefore, there is a need for longer-term, randomized, controlled studies. Moreover, only one study addresses the use of this probiotic during the supportive therapy, in particular in patients with severe forms of periodontitis, and only few patients were included. Patients meeting the criteria of periodontitis stage III and IV, grade C are considered to be affected by severe and advanced forms of periodontitis with a rapid rate of progression. This group of patients could particularly benefit from supplements for the maintenance of periodontal health. The hypothesis of the present randomized controlled trial is that the adjunctive use of probiotic treatment can bring clinical and microbiological advantages during the supportive therapy of periodontal disease, and reduce the number of residual pockets. To test this hypothesis, the patients, upon initial evaluation, will be divided in 2 study groups and, after a session of professional oral hygiene, will be prescribed one of the therapies below: - PLACEBO: The patients of the control group will receive control lozenges without live bacteria; - TEST: The patients of the probiotic group will receive probiotic lozenges containing Lactobacillus reuteri DSM 17938 and Lactobacillus reuteri ATCC PTA 5289 (a minimum of 2 × 108 colony-forming units L. reuteri Prodentis/lozenge, BioGaia AB). The probiotic and control lozenges will be identical in taste, texture and appearance. The lozenges will be given to all patients to consume at home. The patients will be instructed to dissolve them on their tongue twice a day, preferably after brushing, for 3 weeks. Periodontal and microbiological parameters will be evaluated at 3 and 6 months after the initial therapy, and compared between the two groups.

NCT ID: NCT04477551 Recruiting - Clinical trials for Periodontal Diseases

The Effects of Diode Laser as an Adjunct to Non-surgical Periodontal Treatment on Periodontal Status in Patients With Stage III-IV Periodontitis

Start date: July 28, 2020
Phase: N/A
Study type: Interventional

Periodontal disease is serious and global chronic disease. The prevalence of periodontal diseases in United Arab Emirates is not clear but data from Dubai Health Authority showed that one in five patients has received periodontal treatment in recent years. Several studies reported the additional benefits provided by the use of diode laser in combination with ultrasonic debridement in the treatment of gum disease. The use of diode laser may debridement of deep pocketing areas while improving healing of gum tissues. The aim of the study is to compare the effect of removing bacterial deposit (biofilm) from deep tooth pocket using combined diode laser and conventional pocket debridement versus conventional pocket debridement alone on tooth supporting tissue parameters in patients with advanced gum disease (periodontitis). Methodology: A total of 22 patients with advanced gum disease will be randomly allocated to two groups: a control group, which will receive conventional pocket debridement and a test group which will receive ultrasonic debridement with diode laser. Gum measurements will be recorded by a masked calibrated examiner at six points for each tooth and patients' postoperative experience and satisfaction will be assessed using special forms.

NCT ID: NCT04477070 Recruiting - Clinical trials for Periodontal Diseases

The Effects of Subgingival Air-polishing, as an Adjunct to Non-surgical Periodontal Treatment on Periodontal Parameters and Patient Satisfaction in Patients With Periodontitis

Start date: July 21, 2020
Phase: N/A
Study type: Interventional

Periodontal disease is serious and global chronic disease. The prevalence of periodontal diseases in United Arab Emirates is not clear but data from Dubai Health Authority showed that one in five patients has received periodontal treatment in recent years. Several studies reported the additional benefits provided by the use of air-polishing devices in combination with ultrasonic debridement in the treatment of gum disease, their use may reduce postoperative pain and discomfort while providing improvement in gum status. The aim of the study is to compare the effect of removing bacterial deposit (biofilm) from deep tooth pocket using combined air-polishing and conventional pocket debridement versus conventional pocket debridement alone on tooth supporting tissue parameters in patients with advanced gum disease (periodontitis). Methodology: A total of 22 patients with advanced gum disease will be randomly allocated to two groups: a control group, which will receive conventional pocket debridement and a test group which will receive ultrasonic debridement with air-polishing (Airflow Prophylaxis Master, EMS, Nyon, Switzerland). Gum measurements will be recorded by a masked calibrated examiner at six points for each tooth and patients' postoperative experience and satisfaction will be assessed using special forms.

NCT ID: NCT04390789 Recruiting - Clinical trials for Apical Periodontitis

Single And Multiple-visit Endodontic Retreatment Outcome.

Start date: December 15, 2019
Phase: N/A
Study type: Interventional

This study will compare the outcome of single visit retreatment and multi-visit retreatment in cases of failed root canal treated teeth.

NCT ID: NCT04389346 Recruiting - Clinical trials for Chronic Apical Periodontitis

A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates

Start date: July 1, 2019
Phase: N/A
Study type: Interventional

This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.

NCT ID: NCT04381598 Recruiting - Periodontitis Clinical Trials

Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

Start date: April 1, 2019
Phase: Phase 2
Study type: Interventional

With the increase in the incidence of diabetes and obesity, among other artificial sweeteners the need of natural non-caloric sweetener with acceptable taste and without any adverse effects is demanding.So,the use of stevia presents beneficial effects to general and oral health and its properties could result potentially effective in the treatment of periodontal diseases.

NCT ID: NCT04381585 Recruiting - Periodontitis Clinical Trials

Mini Distractor in Vertically Deficient Bone

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

ADO is a bone regeneration technique, introduced by Chin and Toth in 1996 based in a biological process used for regenerate and consolidate bone between two bone segments obtained after osteotomy.These segments have been gradually separated by the process of distraction. ADO can be performed both horizontally (AHDO) and vertically (AVDO).

NCT ID: NCT04375839 Recruiting - Periodontitis Clinical Trials

Zirconia Vs Titanium Implants in Deficient Ridges

Start date: March 6, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate clinically and radiographically soft tissue around single-implant crowns and peri-implant bone resorption respectively by using zirconia implants or titanium implants in horizontally deficient partially edentulous ridges.

NCT ID: NCT04375618 Recruiting - Periodontitis Clinical Trials

RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects

Start date: October 1, 2019
Phase: Phase 1
Study type: Interventional

A sulcular incision will be made through each recession area and the tissues will be gradually undermined including the base of the interdental papilla. At the recession sites rhEGF incorporated absorbable collagen membrane will be gradually manipulated into the pouch through the tunnel till it covers the recession sites and will be stabilized with sutures.

NCT ID: NCT04374383 Recruiting - Periodontitis Clinical Trials

Novel Photosensitizer in The Treatment of Chronic Periodontitis

Start date: June 1, 2019
Phase: Phase 2
Study type: Interventional

The aim of this study is to evaluate the periodontal outcomes after applying antimicrobial photodynamic therapy with a novel photosensitizer as compared to LASER assisted scaling and root planing alone.