Effect of Local Cannabidiol on Clinical & Inflammatory Outcomes in

Status Withdrawn

Clinical Trial Summary

This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient. Unfortunately, periodontology has not yet discovered a therapy that will predictably treat local inflammation in patients who are at risk for further pocketing, bleeding on probing, bone loss and ultimately, tooth loss. Although CBD has been patented in various forms since the 1940s, its acceptance and availability to patients has only recently expanded. Marketing of CBD to periodontal patients as a means to control inflammation is commonplace online and in CBD-specific shops. In determining if CBD is a successful supplement to conventional periodontal inflammation control therapies, millions of patients could benefit from this treatment.

Clinical Trial Description

The purpose of this study is to determine if CBD has any effect on local inflammation in periodontal maintenance patients. This research is significant and innovative as it will act as a pivotal study to determine if CBD is worthy of further study in the area of periodontal disease and it will be a human clinical trial focusing on a specific aspect of periodontal disease, the maintenance patient. Many successful therapies exist for the active, untreated periodontal patient. Unfortunately, periodontology has not yet discovered a therapy that will predictably treat local inflammation in these patients which are at risk for further pocketing, bleeding on probing, bone loss and ultimately, tooth loss. Although CBD has been patented in various forms since the 1940s, its acceptance and availability to patients has only recently expanded exponentially. Marketing of CBD to periodontal patients as a means to control inflammation is already commonplace online and in CBD-specific shops; it is the duty of periodontology to determine the efficacy and success of this known anti-inflammatory compound as it relates to clinical periodontal parameters. To determine if CBD is a successful adjunct to conventional periodontal inflammation control therapies would be a boon to the advancement of oral health and to millions of patients that could benefit from this treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05646459
Study type	Interventional
Source	University of Nebraska
Contact
Status	Withdrawn
Phase	Phase 1
Start date	June 2019
Completion date	May 14, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05065034` - Effects of Antibiotic Therapy on the Short and Long-term Results of Periodontitis Treatments
Completed	`NCT05456555` - The Flapless Approach in Periodontal Regeneration	N/A
Completed	`NCT03851757` - Cleansing Efficacy of Waist-shaped Interdental Brushes.	N/A
Completed	`NCT04240015` - Association of Periodontitis With Oral Health Related Quality of Life
Completed	`NCT05724251` - Effect of Iodine Deficiency on Periodontitis
Completed	`NCT05730153` - Advanced Platelet-rich Fibrin Combined With Open Debridement in Management of Suprabony Periodontal Defects	Phase 4
Not yet recruiting	`NCT06351722` - Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs
Recruiting	`NCT04149834` - Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects	N/A
Completed	`NCT05466253` - Early Versus Delayed Orthodontic Treatment After Periodontal Surgery on Periodontal Health in Periodontally Compromised Patients	N/A
Completed	`NCT04076098` - Locally Delivered Minocycline in Advanced Periodontitis	Phase 4
Active, not recruiting	`NCT03297749` - Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome	N/A
Completed	`NCT05015387` - Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy	Phase 2
Completed	`NCT06064799` - GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients
Completed	`NCT03453476` - Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients	N/A
Completed	`NCT04264624` - Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis	N/A
Completed	`NCT03178838` - Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis	N/A
Recruiting	`NCT03432975` - Evaluation of Multiple Subgingival Irrigations.	N/A
Completed	`NCT05293301` - Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy	N/A
Recruiting	`NCT06149585` - Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Completed	`NCT06064786` - Fetuin A Association in Periodontal Disease and Diabetes Mellitus

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms