Effect of Iodine Deficiency on Periodontitis

Status Completed

Clinical Trial Summary

The goal of this observational study is to compare urine iodine levels of participants with/without periodontitis. The main question it aims to answer is there a relationship between iodine levels of urine and periodontitis. Participants will give urine samples without any intervention.

Clinical Trial Description

Periodontitis is a chronic, inflammatory disease with a cyclical course with active and passive periods, which may result in the destruction of gingival fibers, resorption of alveolar bone, and subsequent tooth loss, by spreading the inflammatory event that started in the gingiva to the tissues supporting the tooth as a result of the effects of bacteria. The disease is closely associated with many systemic conditions. These conditions include diabetes, cardiovascular diseases, respiratory diseases, birth complications, pregnancy, puberty. Iodine deficiency is an important public health problem by affecting 10-15% of the population due to the diseases it causes. Iodine deficiency affects individuals of all ages. When the daily iodine requirement cannot be met, a group of mental, physical and developmental retardation symptoms called "Iodine deficiency disorders" (IEB) (Iodine deficiency disorders-IDD) occur. With the obligatory iodization of table salt, which started in 1998 in order to eliminate iodine deficiency in Turkey, this problem has been tried to be combated by switching to iodized salt consumption. The study material was used by 73 adult individuals who applied to Atatürk University Faculty of Dentistry, Department of Periodontology for different reasons {1. group (H): periodontally healthy individuals, group 2 (P): individuals with periodontitis}. Urine samples will be collected from the participants without any periodontal intervention. Iodine levels in the urine will be studied. There are studies in the literature to determine iodine deficiency and to determine the population periodontal disease status; however, there are no studies evaluating the possible relationship between iodine deficiency and periodontitis. The aim of this study; To evaluate the iodine levels detected in the urine samples of patients with periodontitis by comparing them with healthy controls, and to investigate the possible role of iodine deficiency in the pathogenesis of periodontitis or a simple marker of disease activity in the light of these findings. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05724251
Study type	Observational [Patient Registry]
Source	Ataturk University
Contact
Status	Completed
Phase
Start date	October 30, 2021
Completion date	November 30, 2022

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.