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Periodontal Diseases clinical trials

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NCT ID: NCT06463535 Completed - Diabetes Mellitus Clinical Trials

Effects of Omega-3 as an Adjunct to Non-Surgical Periodontal Therapy on Chemerin Level in Periodontitis Patients With Diabetes: A Randomized Clinical Trial

Start date: June 15, 2023
Phase: N/A
Study type: Interventional

Patient grouping - Group 1 (Type 2 Diabetes Mellitus patients with CPD + SRP and Omega-3) - Group 2 (Type 2 Diabetes Mellitus patients with CPD + SRP) different clinical parameters were recorded ; plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (CAL). 6.Omega-3 poly-unsaturated fatty acids (1000mg) was given as an adjunctive treatment daily for 6 months to group 2, starting 2 weeks after phase 1 therapy.

NCT ID: NCT06408454 Completed - Psoriasis Clinical Trials

Interleukin- 17 (IL-17), Bcl-3, and NF-kappa-B Inhibitor Zeta (IκBζ) Expression Levels in the Psoriasis Patients

Start date: February 1, 2023
Phase:
Study type: Observational

This study aimed to compare the levels of IL-17 (interleukin- 17), Bcl-3 (B-cell lymphoma 3-encoded protein), and IκBζ (NF-kappa-B inhibitor zeta) in the gingival crevicular fluid of psoriatic and healthy individuals and the clinical parameters such as periodontal health, gingival index, plaque index and mobility (using periotest device)in the patient and control groups.

NCT ID: NCT06384638 Completed - Clinical trials for Periodontal Diseases

Coconut Oil in Treatment of Periodontitis

Start date: February 15, 2022
Phase: Phase 1
Study type: Interventional

Virgin Coconut Oil (VCO) is a vegetable oil extracted from coconut fleshcontains unsaturated fatty acids in the form of oleic acid and linoleic acid and flavonoids which function as anti-inflammatory. Periodontitis is an inflammatory disease of the periodontal tissues with a high prevalence worldwide. The main etiology of plaque periodontitis is biofilm containing colonies of pathogenic microorganisms. The aim of the study is to evaluate and compare the effect of scaling and root debridement alone versus the use of topically applied coconut oil as adjunctive to scaling and root debridement in treatment of Stage II and III Grade B periodontitis.

NCT ID: NCT06379022 Completed - Clinical trials for Periodontal Diseases

Proteomic Analysis of Newly Restored Single Implants

Start date: December 3, 2018
Phase:
Study type: Observational [Patient Registry]

In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched. Oral hygiene was closely monitored during the study. Probing pocket depth (PPD), attachment levels (CAL), bleeding and plaque indices and crevicular fluid were collected from an implant-site (PICF) and a tooth-site (GCF). Total proteomic profiles in PICF and GCF were investigated using label-free quantitative proteomics.

NCT ID: NCT06354972 Completed - Clinical trials for Periodontal Diseases

Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration

Start date: January 2, 2022
Phase:
Study type: Observational

Objectives: To test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; SASP) in the gingival crevicular fluid (GCF) on the outcomes of minimally-invasive periodontal regeneration in intra-bony defects. Methods: Sites associated with intrabony defects ≥ 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included. Pre-operatively, GCF was sampled for inflammatory biomarker analysis related to SASP [interleukin (IL)-1β, IL-6 and IL-12; matrix-metalloproteinases (MMP)-8 and -9]. Correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes.

NCT ID: NCT06343337 Completed - Pregnancy Related Clinical Trials

The Effects of Pregnancy on Oral Health

Start date: May 20, 2022
Phase: N/A
Study type: Interventional

The aim of this study was to evaluate the effects of pregnancy on salivary pH, flow rate, caries experience and periodontal status. The main questions it aims to answer are: - Does pregnancy affect caries experience and periodontal status? - Does pregnancy affect salivary pH and flow rate? - Is there a difference between pregnant and non-pregnant woman with respect to caries experience, periodontal status, salivary pH and flow rate? - Is there a difference among first, second and third trimester with respect to caries experience, periodontal status, salivary pH and flow rate?

NCT ID: NCT06316505 Completed - Clinical trials for Periodontal Diseases

Oral Photographs of Patients on Oral Hygiene Motivation

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

Based on these considerations, this randomized controlled trial aimed to determine the effectiveness of a personalized visual oral health education program in addition to conventional education on oral hygiene by comparing changes in clinical periodontal parameters. Participants will get conventional oral hygiene education (COHE) with/without visual motivation using self oral photographs of patients. Researchers will compare Intervention group and control groups on oral hygiene by comparing changes in clinical periodontal parameters.

NCT ID: NCT06306937 Completed - Clinical trials for Periodontal Diseases

Serum Levels of Vitamin D and IL8 in Patients With Periodontitis

Start date: September 1, 2022
Phase:
Study type: Observational

We evaluated vitamin D and IL8 levels in the serum of patients with periodontitis as well as the healthy controls to correlate their levels with the degree of periodontitis.

NCT ID: NCT06293807 Completed - Clinical trials for Periodontal Diseases

Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine

Start date: June 6, 2022
Phase: Early Phase 1
Study type: Interventional

Immediate post-suturing administration of either one of two dental anesthetic solutions or a placebo prior to dismissal.

NCT ID: NCT06291454 Completed - Clinical trials for Periodontal Diseases

GCF Levels of Chemokines in Periodontitis

Start date: January 1, 2023
Phase:
Study type: Observational [Patient Registry]

This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes. A total of 72 individuals, 24 with Stage III Grade B periodontitis (Group 1), 24 with Stage III Grade C periodontitis (Group 2), and 24 periodontally healthy (control group) (Group 3), were included in the study. GCF and clinical periodontal parameters were obtained at baseline. MIP3β and MIP3α levels in GCF were determined by ELISA.