Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration

Status Completed

Clinical Trial Summary

Objectives: To test the impact of clinical inflammation and molecular expression profile (senescence-associated secretory phenotype; SASP) in the gingival crevicular fluid (GCF) on the outcomes of minimally-invasive periodontal regeneration in intra-bony defects. Methods: Sites associated with intrabony defects ≥ 3 mm requiring periodontal regeneration through minimally-invasive surgical technique were included. Pre-operatively, GCF was sampled for inflammatory biomarker analysis related to SASP [interleukin (IL)-1β, IL-6 and IL-12; matrix-metalloproteinases (MMP)-8 and -9]. Correlation analyses and logistic regression models were performed to assess the impact of predictors on clinical and radiographic outcomes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Periodontal Diseases

Clinical Trial Details

NCT number	NCT06354972
Study type	Observational
Source	University of Turin, Italy
Contact
Status	Completed
Phase
Start date	January 2, 2022
Completion date	January 2, 2024

View Details

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