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Pericarditis clinical trials

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NCT ID: NCT05458089 Completed - Clinical trials for Diagnostic Self Evaluation

18F-FDG PET/CT in the Diagnosis of Tuberculous Pericarditis

Start date: January 1, 2015
Phase:
Study type: Observational

A total of 11 patients confirmed with tuberculous pericarditis were enrolled in this study to analyze the diagnostic value of 18F-FDG PET/CT for tuberculous pericarditis.

NCT ID: NCT04906720 Completed - Atrial Fibrillation Clinical Trials

Post-Ablation Pericarditis Reduction Study

PAPERS
Start date: May 20, 2021
Phase: Phase 2
Study type: Interventional

There has not been a prospective, randomized controlled trial of colchicine to reduce post-AF ablation pericarditis in an era of newer AF ablation techniques. The hypothesis is that an empiric pre and post AF ablation treatment protocol with colchicine may reduce the incidence and symptom severity of post-AF ablation related pericarditis. Thus, the goal of this study is to 1. Identify the incidence of post-AF ablation related pericarditis in patients undergoing ablation via high power, short duration strategy (shorter total RF time, but increased stability due to steerable catheters and possible difference from resistive vs conductive heating). 2. Identify potential differences in patients undergoing PVI only versus PVI + additional ablation 3. Identify whether patients on who are already on anti-inflammatories such as ASA or statins have a lower incidence than those without 4. Determine if an empiric treatment strategy with colchicine (for 7 days post ablation) reduces the incidence of post-operative AF

NCT ID: NCT04692766 Completed - Pericarditis Clinical Trials

Study to Evaluate the Efficacy and Safety of RPH-104 Treatment in Patients With Idiopathic Recurrent Pericarditis

Start date: February 12, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this study was to evaluate the Efficacy and Safety of RPH-104 Treatment in patients in comparison to placebo with Idiopathic Recurrent Pericarditis

NCT ID: NCT04623528 Completed - Clinical trials for Pulmonary Hypertension

Characterization of the Liver Parenchyma Using Parametric T1 and T2 Magnetic Resonance Relaxometry

Start date: January 2014
Phase:
Study type: Observational

- To determine normal T1 and T2 values of the liver, and to assess the impact of age and gender - To determine the relation between markers of right heart decompensation and T1/T2 values of the liver in patients with pulmonary hypertension, patients with dilated cardiomyopathy, and patients with constrictive pericarditis (or constrictive physiology) - To determine inter/intra-observer reproducibility for liver T1/T2 assessment - To test/develop multi-feature texture analysis for T1/T2 analysis of the liver and implement machine learning to derive indicative features (MR-derived measures only vs combined with other clinical readouts)

NCT ID: NCT03980522 Completed - Clinical trials for Recurrent Pericarditis

A Pilot Study of KPL-914 in Recurrent Pericarditis

Start date: January 24, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the preliminary efficacy and safety of KPL-914 treatment in participants with recurrent pericarditis.

NCT ID: NCT03737110 Completed - Clinical trials for Recurrent Pericarditis

Study to Assess the Efficacy and Safety of Rilonacept Treatment in Participants With Recurrent Pericarditis

RHAPSODY
Start date: January 7, 2019
Phase: Phase 3
Study type: Interventional

The primary objective of this study was to assess the efficacy of rilonacept treatment in participants with recurrent pericarditis.

NCT ID: NCT02828085 Completed - Clinical trials for Infective Pericarditis

Improvement of the Etiological Diagnosis of the Pericarditis

PERICARDITE
Start date: July 7, 2013
Phase: N/A
Study type: Interventional

Pericardial syndrome includes pericardites acute pericardial effusion and cardiac tamponade, recurrent pericarditis squeezing chronic pericarditis. The etiologies are very numerous and can be classified as infectious, neoplastic, metabolic or systemic, toxic causes. Diagnosis is difficult, and 80% of etiologies remain classified idiopathic. In their laboratory to improve the diagnosis of this syndrome investigators have developed a strategy of systematic prescription of biological tests by kit. This prescription by 'kit' strategy proved its interest by comparison with an intuitive requirement of biological. In this study investigators want to improve the diagnostic causative of pericarditis by implementing a new diagnostic strategy. This new strategy includes (i) samples additional less invasive for the patient, the swab pharyngeal and nasal, (ii) the addition of at the outset of more effective diagnostic techniques: specific Polymerase Chain Reaction (PCR)

NCT ID: NCT02219828 Completed - Clinical trials for Idiopathic Recurrent Pericarditis

AnakInRa for Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP)

AIR TRIP
Start date: June 2014
Phase: Phase 4
Study type: Interventional

Recent findings suggest that recurrent pericarditis (RP) may be a previously unrecognized autoinflammatory disease. The pivotal pathogenic role of interleukin (IL)-1 in RP has been shown by the achievement of complete responses after treatment with the recombinant IL-1-receptor antagonist, anakinra. Anakinra is the recombinant form of IL-1Ra. The proposed study is designed to demonstarate the efficacy of anakinra in RP.

NCT ID: NCT02083510 Completed - Gout Clinical Trials

Apolipoprotein CIII Reduction Via Colchicine

Start date: February 2014
Phase: Phase 0
Study type: Interventional

The aim of this trial will be to determine an effect-size for the administration of chronic low-dose colchicine in the reduction of serum levels of triglycerides (TG), very-low density lipoproteins (VLDL), and apolipoprotein CIII (apoCIII) in human subjects over a period of 4-6 weeks.

NCT ID: NCT01395082 Completed - Myocarditis Clinical Trials

ACAM2000® Myopericarditis Registry

Start date: April 2011
Phase:
Study type: Observational

The purpose of this registry is to study the natural history of vaccination-related myocarditis and pericarditis and to assess possible risk factors for these conditions. Primary Objective: - To document the natural history of confirmed, probable, suspected, and subclinical myocarditis and pericarditis (myopericarditis) following ACAM2000® vaccination. Other Pre-defined Objective: - To look for potential predictive factors for the prognosis of myopericarditis following ACAM2000® vaccination.