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Pulmonary Hypertension clinical trials

View clinical trials related to Pulmonary Hypertension.

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NCT ID: NCT06050525 Recruiting - Acute Kidney Injury Clinical Trials

Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia

Start date: February 1, 2023
Study type: Observational

The main aim of this project is to elucidate the incidence of acute kidney injury (AKI) in newborns with congenital diaphragmatic hernia during stay in the Pediatric intensive care unit. (PICU). This patient group often presents with severe circulatory and respiratory dysfunction requiring intensive care treatment. Characterization of risk factors to AKI will also be performed.

NCT ID: NCT06038149 Not yet recruiting - Clinical trials for Pulmonary Hypertension

Improving Pulmonary Hypertension Screening by Echocardiography

Start date: September 19, 2023
Study type: Observational

This study aims to assess the application of the novel IMPULSE algorithm for the detection of pulmonary hypertension (PH) in those with a low or intermediate probability of PH according to the British Society of Echocardiography (ESC) and European Society of Cardiology (ESC) guidelines.

NCT ID: NCT06031311 Not yet recruiting - Clinical trials for Pulmonary Hypertension

Pulmonaryhypertension in Copd at Different Levels of Smoking

Start date: October 1, 2023
Study type: Observational

To identify Predictors of pulmonary hypertension in COPD patients and its relation to different levels of smoking

NCT ID: NCT06023134 Active, not recruiting - Clinical trials for Pulmonary Hypertension

Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure

Start date: January 1, 2015
Study type: Observational

The study aims to describe the clinical characteristics and clarify the predictors of the short- and long-term outcomes of RHF patients, further assist the diagnosis, risk stratification and treatment of RHF.

NCT ID: NCT05996562 Not yet recruiting - Heart Failure Clinical Trials

Study for Evaluation of Safety and Efficacy of PADN to Treat Combined Post- and Pre- Capillary Pulmonary Hypertension Associated With Chronic Heart Failure

Start date: December 2023
Phase: N/A
Study type: Interventional

The goal of this pilot study is to evaluate the safety and efficacy of pulmonary artery denervation (PADN) in combined post- and pre- capillary pulmonary hypertension (CpcPH) associated with chronic heart failure(CHF). Participants who have received guideline-directed medical therapy (GDMT) according to 2022 AHA/ACC Guidelines for Heart Failure (HF) and have been clinically stable for at least 1 month, will be treated with PADN and followed for 1 year.

NCT ID: NCT05983250 Not yet recruiting - Clinical trials for Pulmonary Hypertension

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

Start date: November 2023
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy of TNX-103 (levosimendan) compared with placebo in subjects with PH-HFpEF as measured by the change in 6-Minute Walk Distance (6 MWD; Day 1 to Week 12).

NCT ID: NCT05980728 Not yet recruiting - Clinical trials for Pulmonary Hypertension

Connective Tissue Disease Patients With Pulmonary Hypertension

Start date: September 1, 2023
Study type: Observational [Patient Registry]

Adult patients with suspected or confirmed Connective Tissue Disease Patients (CTD)With Pulmonary Hypertension(PH)will be recruited. Patients will be approached, consented, have baseline demographics, diagnostics and disease activity measures recorded, and blood taken. The collection of data and biological material will mirror usual clinical practice as far as possible. Subjects will ideally attend further visits at 3, 6 and 12 months to have bloods taken, outcome measures recorded and questionnaires completed.

NCT ID: NCT05958901 Recruiting - Clinical trials for Pulmonary Hypertension

Pulmonary Hypertension Observational Study

Start date: July 12, 2023
Study type: Observational

The purpose of this study is to establish the large PH cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices.

NCT ID: NCT05937854 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Start date: October 18, 2023
Phase: Phase 2
Study type: Interventional

The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, and lung function. Veterans who enroll in the trial will be allocated by chance to either active tadalafil or an inactive identical capsule (placebo). Neither the Veteran nor the investigator will know whether the Veteran is taking tadalafil or placebo. Veterans will be followed closely in clinic or by telephone at 1, 2, 3, 4, 5, and 6 months, with attention to side effects and safety. At 1,3, and 6 months the investigators will repeat the questionnaires and testing of blood pressures in the lung and lung function. The investigators anticipate that the results of this study will determine whether tadalafil improves shortness of breath when added to usual medications for COPD.

NCT ID: NCT05935865 Recruiting - Clinical trials for Pulmonary Hypertension

Monitoring of the Influence of Approved PH-therapies RV-PA Coupling

Start date: February 13, 2023
Study type: Observational

The goal of this observational study is to learn about the acute (days) changes in right ventricular functions caused by initiation of pharmacological therapies in patients with precapillary pulmonary hypertension. The main question it aims to answer is: • Course of afterload and intrinsic contractility throughout the hospital stay Participants will be equipped with a device for continuous monitoring and recording of the right ventricular pressure signal.