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Pericarditis clinical trials

View clinical trials related to Pericarditis.

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NCT ID: NCT00810849 Completed - Clinical trials for Tuberculous Pericarditis

A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis

IMPI
Start date: December 2008
Phase: Phase 3
Study type: Interventional

Human immunodeficiency virus (HIV) infection puts people at risk of opportunistic infections, such as tuberculosis. In Africa, the HIV epidemic has resulted in an increase in the number of cases of tuberculosis affecting various parts of the body, including the membrane surrounding the heart (i.e., pericardium). Pericardial tuberculosis is a serious form of tuberculosis that results in the death or disability of 1 in 2 affected people despite the use of antituberculosis medication. It has been suggested that the addition of corticosteroids to the antituberculosis medication could result in the reduction of the number of deaths caused by the disease, but this proposal remains to be confirmed in appropriately designed clinical trials. Similarly, vaccination with the Mycobacterium w injection is also proposed as a possible way of reducing the damage caused by the tuberculosis infection of the heart. The investigators are proposing to conduct a clinical trial in which people who are on antituberculosis treatment for pericardial tuberculosis will be randomly allocated to receive either prednisolone or a matching placebo tablet, or Mycobacterium w injection or placebo injection. The number of people who die or who develop hardening of the pericardium with compression of the heart (called pericardial constriction) or who need emergency evacuation of the pericardial fluid from pericardial sac for severe compression (called tamponade) will be compared in each group to determine whether the use of corticosteroids or Mycobacterium w injection is safe and results in reduction in the death rate. If corticosteroids and Mycobacterium w are shown to safely reduce the death rate, then they will be recommended for use in all patients with tuberculosis of the pericardium in the future.

NCT ID: NCT00235079 Completed - Recurrence Clinical Trials

Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment.

CORP 2
Start date: November 2005
Phase: Phase 4
Study type: Interventional

The purpose of the study is to determine whether colchicine is safe and effective in treatment and prevention of recurrent pericarditis after failure of conventional treatment.

NCT ID: NCT00128453 Completed - Pericarditis Clinical Trials

Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences

Start date: August 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine whether colchicine is safe and effective in the treatment of acute pericarditis and the prevention of subsequent recurrences.

NCT ID: NCT00128414 Completed - Recurrence Clinical Trials

Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode)

CORP
Start date: August 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine whether colchicine is safe and effective in the treatment and prevention of recurrent pericarditis (first episode).