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Periapical Periodontitis clinical trials

View clinical trials related to Periapical Periodontitis.

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NCT ID: NCT04104789 Withdrawn - Clinical trials for Apical Periodontitis

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General

Start date: September 2020
Phase: Phase 2
Study type: Interventional

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

NCT ID: NCT04072926 Completed - Clinical trials for Apical Periodontitis

Effects of PDT and Bioceramic Filling on Periapical Healing and Postoperative Pain After Endodontic Retreatment

Start date: October 16, 2019
Phase: Early Phase 1
Study type: Interventional

The purpose is to investigate influence of bioceramic filling of the root canal and photodynamic therapy on periapical healing and development of postoperative pain after endodontic retreatment. Patients are divided into two main groups and each of the group is divided into two subgroups. Main groups are patients receiving photodynamic therapy and patients receiving passive ultrasonic irrigation. Each of the main group is divided by the root canal filling material on the AH+ group and BioRoot group.

NCT ID: NCT04018456 Completed - Clinical trials for Apical Periodontitis

Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis

Start date: August 1, 2021
Phase: N/A
Study type: Interventional

The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation root canal treatment in mature single canal with pulp necrosis and apical periodontitis.

NCT ID: NCT03990584 Completed - Clinical trials for Root Canal Infection

Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using different methods of irrigation activation.

NCT ID: NCT03987659 Completed - Clinical trials for Apical Periodontitis

Therapeutic Irrigation Procedures to Treat Apical Periodontitis

TIPTAP
Start date: October 1, 2019
Phase: N/A
Study type: Interventional

Apical periodontitis is a dental infection which develops around the root of a tooth and affects ~4-6% of the UK population. Current treatment strategies focus solely on removing bacteria from within the root canal space during Non-Surgical Root Canal Treatment (NSRCT). Despite radical improvements in techniques available to disinfect canals, over the last 2-3 decades there has been no proportionate improvement in success rates, with ~20% of cases failing to demonstrate complete healing following NSRCT. Over time this has placed significant burden on public resources as evidenced by increased referrals to dental hospitals, extensive waiting lists and increased use of anti-microbials. It has long been known numerous bioactive molecules (dentine extracellular matrix components [dECM]) exist within the structure of the dentine. In a laboratory setting, they have demonstrated significant antibacterial properties and the ability to induce the functional processes of dental tissue repair. Through a different irrigation procedure, this research group have optimised methods for releasing dECMs during NSRCT and hypothesise this intervention could potentially promote a reduction in inflammation, improve healing and lead to more favourable outcomes for patients suffering from apical periodontitis, a concept which has not yet been investigated. It is proposed that to test this hypothesis at the Birmingham Dental Hospital by comparing clinical/radiographic signs of periradicular healing, and the molecular inflammatory response, in patients undergoing standard NSRCT (control arm) to those who having NSRCT with an irrigant regime that promotes release of dEMCs (intervention arm). Data generated from this randomised controlled pilot study will not only help to understand the process of healing following treatment of apical periodontitis at a molecular level, but also help to explore if there is therapeutic potential in enhancing dEMC release during NSRCT.

NCT ID: NCT03962634 Terminated - Clinical trials for Apical Periodontitis

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric

Start date: August 28, 2019
Phase: Phase 2
Study type: Interventional

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

NCT ID: NCT03918733 Active, not recruiting - Clinical trials for Periapical Periodontitis

Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature. Two systematic reviews conducted to explore the issue also could not draw any definitive conclusions and suggested that further research is necessary to find out effects of surgical versus nonsurgical approach. Considering the very limited amount of data on this pertinent topic, there is apparent need of high quality randomized controlled studies to further investigate the difference in outcome between nonsurgical retreatment and endodontic surgery.

NCT ID: NCT03743987 Completed - Wound Heal Clinical Trials

The Effect of MTA and PRF Application in Periapical Lesions

Start date: December 20, 2016
Phase: N/A
Study type: Interventional

A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form. Groups were divided in to 4; as control, MTA (mineral trioxide aggregate), PRF (platelet rich fibrin) and MTA+PRF groups. Apical resection was performed in all groups. No other interventions were made to the control group. Routine radiographs were taken in the 1st. 3th and 6th months. In the (approximately) 12th month of the procedures computerized tomography scans were taken. Primary healing of the periapical tissues were evaluated and the outcomes were measured. Patients have still been under control for the long term outcomes of the study.

NCT ID: NCT03711942 Completed - Clinical trials for Apical Periodontitis

Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients.

Start date: October 15, 2016
Phase: N/A
Study type: Interventional

Periodontal health may jeopardize the success of endodontic treatment.Intraorifice barrier apart from enhancing probability of success of endodontic treatment may also augment periodontal therapy as intra pulpal infection is known to contribute in worsening of periodontal health by promoting marginal bone loss and pocket formation.This study compared the apical healing in healthy and periodontally compromised teeth and evaluated the effect of intra orifice barrier and base in the healing of apical periodontitis.

NCT ID: NCT03708081 Completed - Pulpitis Clinical Trials

Comparative Evaluation of Different File Systems in Postoperative Pain

Start date: June 1, 2017
Phase:
Study type: Observational [Patient Registry]

Postoperative pain is a frequent complication associated with root canal treatment. The apical extrusion of irrigant and debris, including bacteria and necrotic tissue, may lead to postoperative pain, periapical inflammation, and flare-ups. The instrumentation technique and the file design may affect the amount of debris extrusion. The aim of this study was to evaluate the influence of instrumentation techniques on the incidence and intensity of postoperative pain after single-visit root canal treatment.