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Parkinson Disease clinical trials

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NCT ID: NCT05385497 Recruiting - Parkinson's Disease Clinical Trials

Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD

Start date: November 7, 2022
Phase: N/A
Study type: Interventional

This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD. Results from this work will provide insight into whether combination interventions utilizing AE and VR have parallel effects on cognition, gait, and neuroplasticity in PD.

NCT ID: NCT05385315 Recruiting - Parkinson Disease Clinical Trials

Towards the Validation of a New Blood Biomarker for the Early Diagnosis of Parkinson's Disease

BIOPARK
Start date: October 13, 2022
Phase:
Study type: Observational

The investigators have recently discovered a metabolic biomarker which predicts Parkinson's disease (PD) at the early stages in patients and in animal models. The aim of BIOPARK is to investigate how the biomarker evolves in advanced PD stage, when diagnosis confirmation is higher, an in de novo PD patients who come from a different geographical area than those of the publication (since it is known that the metabolome is largely influenced by lifestyle). They will also evaluate if the biomarker is able to distinguish patients with a parkinsonian syndrome often confused with parkinson's disease, i.e. Multiple System Atrophy (MSA).

NCT ID: NCT05382858 Recruiting - Parkinson Disease Clinical Trials

PSA Versus STN DBS for TD-PD

PSA-STN
Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effectiveness of the deep brain stimulation in the posterior subthalamic area (PSA) versus the subthalamic nucleus (STN) for the treatment of tremor-dominant Parkinson's disease (PD) in a randomized, double-blinded, cross-over manner.

NCT ID: NCT05377281 Recruiting - Parkinson's Disease Clinical Trials

Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)

GUIDE
Start date: July 7, 2022
Phase: Phase 1
Study type: Interventional

This is an open-label, non-randomized, single-arm trial design to actively follow participants for 12 months. Ten participants will be enrolled to receive bilateral delivery of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain Stimulation (DBS) surgery. After 12 months, participants will be followed long term through annual visits for the rest of their lives. Participants will serve as their own donor for the tissue.

NCT ID: NCT05376761 Recruiting - Clinical trials for PD - Parkinson's Disease

EC50 of Dexmedetomidine in Deep Brain Stimulation Implantation of Patients With Parkinson's Disease

Start date: May 31, 2022
Phase: Phase 4
Study type: Interventional

Dexmedetomidine (DEX) sedation is widely used in deep brain stimulation implantation (DBSI) of patients With Parkinson's disease. However, intraoperative application of DEX may affect the discharge activity of deep brain nuclei and reduce the discharge frequency of Subthalamic nucleus (STN) neurons. At present, there is still a lack of prospective intervention research to explore the optimal dose that does not affect MER mapping in patients with Parkinson's disease. The present study uses the Dixon and Massey up-and-down method to analyze the EC50 of DEX in patients with PD undergoing STN-DBS sedation, to clarify the balance meets the sufficient comfort of patients without affecting the accurate target of MER and the optimal dosage of DEX for boundary recognition.

NCT ID: NCT05370079 Recruiting - Clinical trials for Parkinson's Disease; Amyotrophic Lateral Sclerosis; Glioblastoma; Cancer Without Neurological Disease; Rheumatoid Polyarthritis

Control Cohort CTRL COH

CTRL COH
Start date: August 8, 2023
Phase: N/A
Study type: Interventional

Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare disease that could be difficult to diagnose. So it necessary to obtain numerous sample from different disease to develop more specific diagnosis kit It could be possible through the characterisation of new genetic biomarkers.

NCT ID: NCT05363046 Recruiting - Parkinson's Disease Clinical Trials

Noninterventional Study Evaluating Parkinson's Disease Diary Use

Start date: July 29, 2022
Phase:
Study type: Observational

This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide adequate control of symptoms.

NCT ID: NCT05361200 Recruiting - Parkinson Disease Clinical Trials

Speed Manipulated Adaptive Rehabilitation Therapy Bike for Parkinson's Disease

SMART
Start date: April 11, 2022
Phase: N/A
Study type: Interventional

Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability. These symptoms significantly affect PD patients' quality of life, independence, and functional performance. There is currently no cure for PD, but symptoms can be treated with levodopa or deep brain stimulation surgery. Exercise-based rehabilitation has similar beneficial effects to surgical and pharmacological management without the potential negative side effects. Cycling-based interventions have been shown to increases motor function and mobility in individuals with PD. Specifically, benefits are greater when cycling cadence (revolutions per minute, RPM) is 30% greater than a self-selected pace. Although high cadence cycling improves motor function in individuals with PD, there is significant heterogeneity in individual responses. To maximize the treatment effects and minimize the heterogeneity of high-cadence cycling, it is important to determine patient-specific settings. Previous studies have shown that higher variability (entropy) of cadence leads to greater improvement in motor function. The entropy of cadence calculation will be utilized to understand how patient-specific settings can drive improvements. The purpose of this study is to determine patient-specific settings and measure the effects of high cadence stationary (i.e. dynamic) cycling on functional performance in individuals with PD. Volunteers with Parkinson's disease will complete 12 cycling sessions over a 1-month period and measures of motor function, quality of life, functional performance, mood and exercise readiness will be collected.

NCT ID: NCT05357638 Recruiting - Multiple Sclerosis Clinical Trials

Physical Training for People With Parkinson's Disease and Multiple Sclerosis: Effect on Mind and Body

HersenFIT
Start date: May 2, 2022
Phase: N/A
Study type: Interventional

People with Parkinson's disease and Multiple Sclerosis experience disabling motor and non-motor symptoms, which respond insufficiently to medication. To adequately alleviate disease burden, physical training is increasing acknowledged as an assisting therapy; however, the optimal dose of exercise in unknown.

NCT ID: NCT05357612 Recruiting - Parkinson Disease Clinical Trials

Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases

Start date: January 23, 2023
Phase: Phase 4
Study type: Interventional

It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group. This will be tested by measuring 5HT2A receptor density using the PET radioligand (R)-[18F]MH.MZ in both populations.