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Pancreatic Diseases clinical trials

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NCT ID: NCT04949282 Recruiting - Neoplasms Clinical Trials

Spanish Series of Patients Treated With the Radionuclide Lutetium177

SEPTRALU
Start date: May 10, 2021
Phase:
Study type: Observational

This study aims to pool the clinical experience of Spanish centers treating patients with 177Lu-DOTATATE to evaluate the efficacy, tolerance, and safety of the drug in routine clinical practice and to learn about the profiles of patients and tumors treated and the results in each type of patient and tumor.

NCT ID: NCT04932785 Recruiting - Pancreatitis Clinical Trials

Regular vs. Clear Liquid Diet for Mild to Moderate Acute Pancreatitis

Start date: July 18, 2021
Phase: N/A
Study type: Interventional

Acute pancreatitis is among the most common gastroenterology diagnosis in the United States, and represents a large economic burden to the United States health system. While recent guidelines agree early feeding shortens length of stay, these guidelines fail to provide recommendations on optimal diet to start leaving diet type to clinician discretion. Therefore, the aim is to assess the comparative efficacy of full calorie regular diet (RD) versus clear liquid diet (CLD) on length of hospital stay (LOHS) for mild to moderate acute pancreatitis (AP). The study population will target mild to moderate acute pancreatitis patients who can tolerate eating in a single institution. The primary end point will focus on LOHS, and secondary end points will include Pancreatic Activity Scoring System, side effects and readmission.

NCT ID: NCT04701567 Recruiting - Liver Diseases Clinical Trials

Diagnostic and Evaluation of Hepato-pancreatico-biliary Disease With MRI

Start date: June 30, 2020
Phase:
Study type: Observational

This is a retrospective review of images from patient data. There is no recruitment necessary for this study. Research Question: Can advanced multiparametric MRI techniques improve the detection and characterization of focal and diffuse liver disease, accurately assess treatment response and predict patient outcomes based on longitudinal monitoring? Hypotheses: Advanced multiparametric MRI techniques improve the detection, characterization and response assessment of focal and diffuse liver disease and can predict serious liver related outcomes.

NCT ID: NCT04668781 Recruiting - Pancreas Cancer Clinical Trials

Improvement of Care of Patients Undergoing Pancreaticoduodenectomy

Start date: December 21, 2020
Phase: N/A
Study type: Interventional

The study is a randomised controlled trial comparing the effectivity and impact of epidural analgesia and wound catheter analgesia in patients undergoing pancreaticoduodenectomy. The aim of the study is to examine whether there are a difference in perioperative fluid therapy and complication rates between the patients in epidural and wound catheter groups.

NCT ID: NCT04556019 Recruiting - Liver Diseases Clinical Trials

Results of Surgical Treatment of the Hepatobiliopancreatic Surgical Unit

HPB
Start date: January 3, 2019
Phase:
Study type: Observational

The main aims of this study are: 1. - to evaluate post-surgical morbidity and mortality outcomes, following the criteria and the definitions from Claven-Dindo and ISGPS international classifications, of the patients operated by the HPB Surgical Unit. 2. - to evaluate survival and disease-free survival rates of the patients operated by the HPB Surgical Unit due to tumoral cause.

NCT ID: NCT04493632 Recruiting - Neoplasms Clinical Trials

OSPREY is a Post-market, Global, Multicentre, Observational, Prospective Registry.

OSPREY
Start date: April 12, 2022
Phase:
Study type: Observational [Patient Registry]

The OSPREY Patient Registry has been developed to collect and assess the performance and safety of the OncoSilâ„¢ device when used within the approved indication of unresectable, locally advanced pancreatic cancer, in combination with gemcitabine-based chemotherapy, within a real-world observational registry. The Registry data will provide both complementary and contemporary information to the existing clinical data across various countries and will form part of the post-market clinical follow-up activities for OncoSilâ„¢. Therefore, the Registry will be implemented only in countries with regulatory (commercial) approval for the OncoSilâ„¢ device.

NCT ID: NCT04443595 Recruiting - Pancreatitis Clinical Trials

Dual-scopic Pancreatic Necrosectomy (DPN)

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

The LPN procedure is performed under general anesthesia. The transperitoneal access to peripancreatic space is via the gastro-colic ligament and greater omentum, effusion and pus is removed by laparoscopic forceps and suction. Laparoscopic cholecystectomy (LC) is performed during the LPN procedure on patients with indication. The NPN procedure is followed by the standard retroperitoneal approach. After the catheter is exchanged over a guide wire and serially dilated up from 6F to 24F followed by Seldinger technique, the access track to the necrotic cavity is established. A nephroscope is inserted into the cavity through the track for debridement. Using forceps and suction, the peripancreatic solid necrotic tissue and pus is grasped and removed. A large-bore irrigating drain is left in the cavity, with continuous irrigation by warm normal saline solution at a rate of 100-125 ml/h after surgery.

NCT ID: NCT04438447 Recruiting - Pancreas Disease Clinical Trials

ERAS Versus ERAS Plus Artificial Nutrition in Open Pancreatoduodenectomy

RASTA
Start date: April 14, 2022
Phase: N/A
Study type: Interventional

there is a need of a randomised clinical trial specifically design to explore whether given a full nutritional requirement by parenteral feeding in the first 5 days after surgery coupled with oral food "at will" compared to only oral food "at will", within an established ERAS program, could achieve a reduction of the morbidity burden

NCT ID: NCT04391426 Recruiting - Microbiota Clinical Trials

Analysis of Biliary Microbiota in Hepatobiliopancreatic Diseases Compared to Healthy People [MICROBILIO]

Start date: June 3, 2021
Phase:
Study type: Observational

The performance of the microbiota is observed in all clinical and pathological stages of carcinogenesis, since its development, diagnosis and treatment, including prognosis and survival. However, it was found that there is a scarcity of studies on biliary microbiota and its relationship with hepatobiliopancreatic diseases. Therefore, further investigation is necessary, since reaching the biliary microbiota may suggest ways for studies of biomarkers, diagnoses, tests and therapies in hepatobiliopancreatic diseases. For this, bile samples will be collected in cases and controls patients to characterize the microbiota and its variations according to the disease.

NCT ID: NCT04291651 Recruiting - Pancreatic Cancer Clinical Trials

UCSF PANC Cyst Registry

UCSF PCR
Start date: October 8, 2019
Phase:
Study type: Observational [Patient Registry]

Pancreatic cysts are found incidentally on 15-50% of CT and MRIs for all indications and their prevalence is increasing. Many of these cysts may be precursors to pancreatic cancer, and thus pose a substantial risk, however, the vast majority are benign. Increased detection of pancreatic cysts provides an opportunity to diagnose pancreatic malignancy at an early, curable stage yet also increases the potential to over-treat clinically insignificant lesions. This presents a clinical challenge to prevent unnecessary resection of indolent disease, with associated risks of infections, bleeding, diabetes, and costly disability. Unfortunately, there is little information on the epidemiology and natural history of pancreatic cysts to help guide management.