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Pancreas Disease clinical trials

View clinical trials related to Pancreas Disease.

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NCT ID: NCT06298604 Recruiting - Liver Diseases Clinical Trials

Motorized Fine Needle Biopsy vs Standard Needles

Start date: December 9, 2023
Phase: N/A
Study type: Interventional

Recent improvements in punctures techniques and needles now allow for the collection of high-quality specimens comparable to core needle biopsy. A newly developed motorized fine needle biopsy (mFNB), the Precision-GI (Limaca, Israel) promises intact tissue acquisition without sample damage, relying on controlled axial tissue cutting and high-speed rotational coring for optimized tissue acquisition. Given the advancement mentioned, the investigators aim to compare the performance of the mFNB with the standard needle during the acquisition of endoscopic ultrasound (EUS)-guided pancreatic and liver specimens through a prospective, interventional, single-center trial. The study will consist of two groups of patients: one assigned to the standard fine needle biopsy (FNB) and the other to the mFNB. The primary study outcomes will include sample quality (core integrity), and diagnostic accuracy.

NCT ID: NCT06160154 Completed - Pancreas Disease Clinical Trials

Minimally Invasive Robot-assisted and Laparoscopic Distal Pancreatectomy in a Pan-European Registry

Start date: January 1, 2019
Phase:
Study type: Observational

A planned analysis of outcomes among consecutive patients after MIDP from centers participating in the E-MIPS registry (2019-2021). Main outcomes of interest were intraoperative events, major morbidity (Clavien-Dindo grade ≥3) and 30-day/in-hospital mortality.

NCT ID: NCT06135233 Completed - Pancreas Disease Clinical Trials

Implementation and Outcome of Minimally Invasive Pancreatoduodenectomy in Europe:

E-MIPS
Start date: January 1, 2019
Phase:
Study type: Observational

A planned analysis of outcomes among consecutive patients after MIPD from centers participating in the E-MIPS registry (2019-2021). Main outcomes of interest were major morbidity (Clavien-Dindo grade ≥3) and 30-day/in-hospital mortality.

NCT ID: NCT05714111 Recruiting - Pancreatic Cancer Clinical Trials

Radiology Registry on Pancreatic Malignancies

RadonPams
Start date: March 4, 2022
Phase:
Study type: Observational

The purpose of this study is to collect all radiological data which evaluated with clinical data may help assess malignancy and prognosis of pancreatic disease.This registry aims to collect retrospective data from 2014 and prospective data until 2027 with a maximum follow-up of 3 years per patient.

NCT ID: NCT05431556 Recruiting - Pancreas Disease Clinical Trials

Virtual Mind-Body Exercises for People Having Pancreatic Surgery

Start date: June 17, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to find out if it is practical to provide 2 interventions, VMB exercise classes and EUC (pre-recorded self-care videos), during the perioperative period (before and after surgery) to improve health-related outcomes and quality of life for people undergoing a pancreatectomy.

NCT ID: NCT05356039 Recruiting - Quality of Life Clinical Trials

Survival, Quality of Life and Resectability in Locally Advanced Pancreatic Cancer

SQUARE
Start date: April 19, 2022
Phase:
Study type: Observational

This study aims to assess overall survival, quality of life and resection rates in locally advanced pancreatic cancer

NCT ID: NCT05333991 Completed - Pancreas Disease Clinical Trials

Endothelial Leakage and the Association to Endothelial Biomarkers After Surgery

Start date: August 31, 2022
Phase:
Study type: Observational [Patient Registry]

The primary aim of this study is to investigate fluid loss from the blood stream (''endothelial leakage'') and the damage on the vessel wall (''endothelial function'') during surgery. Cardiovascular complications during surgery are said to have different causes, e.g. lack of fluid in the blood stream (''hypovolemia'') and decreased vascular tone. Hypovolemia can have different causes, one being damage to the endothelial function. During trauma and infection, it has been previously shown, that damage to the endothelial function causes fluid loss from the blood stream. Nevertheless, this has never been demonstrated during surgery. Secondary this study will measure the blood flow using a thermo-camera during surgery. This will together with selected blood tests provide information on various possible causes to hypovolemia. The purpose of this study is to describe and quantify endothelial damage (assessed by selected endothelial biomarkers) and albumin escape rate as a proxy for endothelial leakage (assessed by measuring radioactive 125-I labeled HSA injected postoperatively), combined with assessment of MTS (assessed by Laser Speckle Contrast Imaging (LSCI) and digital thermography). This will allow a detailed description of the surgery's impact on the endothelial integrity and contribute to a better understanding of the physiological changes that occur postoperatively. The study will investigate patients undergoing pancreaticoduodenectomy (Whipple) and total pancreatectomy. These patients have a vast clinical need, being one of the most extensive abdominal surgical procedures with great stress response. The study is a prospective exploratory cohort study and methods include blood sampling pre- and post-operatively, 125-I labeled humane serum albumin postoperatively (and preoperatively if logistically possible) and thermography. The hypothesis of this study is that the extent of endothelial damage measured by selected biomarkers is associated with the level of albumin escape rate after major abdominal surgery. Secondly, inflammation increases albumin escape rate after major abdominal surgery.

NCT ID: NCT05155878 Recruiting - Surgery Clinical Trials

Prognostic Factors in Periampullary Tumors and Cysts

Start date: September 1, 2021
Phase:
Study type: Observational [Patient Registry]

The project aims at analysing prognostic and predictive factors involved in diagnostics and surgical treatment of cysts and tumors in the pancreas and periampullary region using both clinical data and blood and tissue samples for biomarker development and validation.

NCT ID: NCT05139394 Completed - Emergencies Clinical Trials

Emergency Pancreaticoduodenectomy: a Non-trauma Center Case Series

Start date: January 2014
Phase:
Study type: Observational

Pancreaticoduodenectomy is a challenging procedure itself, being even more complex and demanding in emergency settings. Only a few cases of emergency pancreaticoduodenectomy (EPD) are reported in medical literature, usually performed for complex pancreaticoduodenal lesions. EPD has first been mentioned in trauma settings, even fewer cases being reported for non-traumatic indications. The investigators intend to present our experience with this intervention, in a non-trauma surgical centre. Our study is a prospective consecutive case series, that included patients that underwent emergency pancreaticoduodenectomy from January 2014 to May 2021. Data was collected from the electronic system database. The investigators collected data regarding the demographic characteristics of the patients, their medical history, preoperative and postoperative investigations (including blood work and imagistic investigations), surgery related information and postoperative evolution.

NCT ID: NCT04900012 Not yet recruiting - Clinical trials for Surgery--Complications

Prospective Snapshot Audit of Distal Pancreatectomy in Spain

Spadispan
Start date: July 1, 2021
Phase:
Study type: Observational

Distal pancreatectomy is the surgical technique performed to treat many pancreatic diseases located in neck and tail of the pancreas. Laparoscopic approach is the gold standard but in many centres the percentage of laparoscopic approach is still low. This technique has low mortality but 30% morbidity mostly related to pancreatic fistula. Some new devices (linear stapler, energy devices and patches) seem to decrease pancreatic fistula but there is not evidence based medicine that confirm the results published usually in unicentric studies.