Pain Clinical Trial
Official title:
Brain Morphometric Study in Knee Osteoarthritis Patients Treated With Duloxetine
This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.
In this study, all the participants will be receiving placebo. However this study will be
single blinded in that participants will be told that they will be given a pill that may or
may not help with their pain. The researcher, however, will know that all participants are
receiving placebo
At the initial visit, participants will undergo screening to determine that they meet all
inclusion and exclusion criteria. They will sign consent and then complete pain assessment
instruments as well as one high resolution anatomical scan (T1) and one functional scan (a
resting scar) in a 3 Tesla magnet. A single scanning session comprised of a 10 minute
functional scan (a resting scan) will be done two weeks from the first scan and pain
assessment instruments will be completed at this visit as well. After finishing this second
scan (done two weeks after the initial scan), the participants will have completed the
study.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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