Pain Clinical Trial
Official title:
Effects of Low Dose Buprenorphine on Recovery After Hip or Knee Arthroplasty
Buprenorphine is a highly lipophilic thebaine derivative that appears to have high affinity
for mu-, kappa-, and delta-opioid receptors and low affinity for opioid receptors like 1
-receptors. It acts as a partial agonist at the mu-opioid and as a partial
agonist/antagonist at the kappa-opioid, and as an antagonist at the delta opioid receptors.
Buprenorphine has up to two-fold duration of action and it is approximately 30-fold more
potent when compared to morphine.
Pain is a common problem in patients coming to joint arthroplastic surgery. Buprenorphine
low dose patches are recommended for treatment of moderate pain for example osteoarthritis
pain. It is known that well treated pain even preoperatively may prevent prolonged
postsurgical pain.
In the present study the effects of low dose buprenorphine on postoperative pain and
recovery were assessed.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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