Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Pain Clinical Trial

Official title:

Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02570230
• Other study ID #: SI2558
• Status: Completed
• Phase: Phase 4
• Start date: October 1, 2017
• Est. completion date: December 31, 2018

Study information

• Verified date: August 2021
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: December 31, 2018
• Est. primary completion date: December 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• ASA physical status 1-3

• elective thoracotomy

• can operate patient-controlled analgesia (PCA) machine

Exclusion Criteria:

patient with history of

• allergy to morphine or ketamine

• contraindicate to ketamine

• remain intubated in the postoperative period

Related Conditions & MeSH terms

• Pain
• Postoperative Period

Intervention

Other:
• NSS
NSS infusion

Drug:
• Ketamine
Ketamine 0.2 mg/kg/hr intravenous infusion

Locations

Country	Name	City	State
Thailand	Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to first trigger of morphine	Time to first trigger of morphine	24 hours
Secondary	24-hr morphine consumption	24-hr morphine consumption	24 hours
Secondary	NRS score at 6, 24 hours	NRS score (0-10) was assessed at at 6, 24 hours postoperative	24 hours
Secondary	Incidence of nausea and vomiting	Incidence of nausea and vomiting	24 hours