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NCT02570230 Clinical Trial

Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Pain Clinical Trial

Official title:
Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02570230
Other study ID # SI2558
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date October 1, 2017
Est. completion date December 31, 2018

Study information
Verified date August 2021
Source Mahidol University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Recruitment information / eligibility
Status Completed
Enrollment 32
Est. completion date December 31, 2018
Est. primary completion date December 31, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - ASA physical status 1-3 - elective thoracotomy - can operate patient-controlled analgesia (PCA) machine Exclusion Criteria: patient with history of - allergy to morphine or ketamine - contraindicate to ketamine - remain intubated in the postoperative period

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• NSS
NSS infusion
Drug:
• Ketamine
Ketamine 0.2 mg/kg/hr intravenous infusion

Locations
Country Name City State
Thailand Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University Bangkok

Sponsors (1)
Lead Sponsor Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

Outcome
Type Measure Description Time frame Safety issue
Primary Time to first trigger of morphine Time to first trigger of morphine 24 hours
Secondary 24-hr morphine consumption 24-hr morphine consumption 24 hours
Secondary NRS score at 6, 24 hours NRS score (0-10) was assessed at at 6, 24 hours postoperative 24 hours
Secondary Incidence of nausea and vomiting Incidence of nausea and vomiting 24 hours
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