Does Preventive Dexketoprofen Reduce Pain After Orthognathic Surgery

Pain, Postoperative Clinical Trial

Official title: Does Preventive Single Dose of Intravenous Dexketoprofen Reduce Pain and Swelling After Orthognathic Surgery? A Prospective, Randomized, Double Blind Clinical Trial

Status Completed

Clinical Trial Summary

Background The purpose of this study was to evaluate the effect of a single-dose intravenous dexketoprofen administration for preventive analgesia on postoperative pain and reducing swelling in double jaw surgery.

Material and Methods The authors designed a prospective, randomized, and double-blind cohort study. Patients who have Class III malocclusion were randomly divided in two groups. 50 mg intravenous dexketoprofen trometamol were administrated 30 minutes before incision in treatment group, while intravenous sterile saline was administrated 30 minutes before incision in placebo group. The primary predictor variable was treatment group. Primary outcomes were pain, swelling and 24-hour opioid intake. Patient- controlled analgesia with tramadol was given for management of postoperative pain. Other variables were demographic and operation related parameters. Visual analogue scale was used to evaluate postoperative pain. 3dMD Face System (3dMD, USA) was used to measure postoperative swelling. Data were analysed using two independent samples t test and Mann Whitney U test.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Pain, Postoperative

• NCT number: NCT05303688
• Study type: Interventional
• Source: TC Erciyes University
• Status: Completed
• Phase: N/A
• Start date: March 1, 2018
• Completion date: February 1, 2019