Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

Status Completed

Clinical Trial Summary

Exparel has been shown to have better pain control compared to previously used infiltration agents, including bupivacaine, while having a minor side effect profile. The purpose of this study is to explore the effectiveness of Exparel (liposomal bupivacaine) in Adductor Canal Blocks for peri-operative pain control following a total knee arthroplasty (TKA) procedure.

Clinical Trial Description

The effectiveness of an Exparel Block (Bupivacaine Liposomal Injectable Suspension) for post-operative pain control has been well studied with encouraging results. At the investigators' institution, Exparel has been approved as a safe and effective option for use in shoulder surgeries and have had encouraging results in adductor canal use for pain control in patients undergoing TKA. Exparel has been shown to have better pain control compared to previously used infiltration agents, including bupivacaine, while having a minor side effect profile. The purpose of this study is to explore the effectiveness of Exparel (liposomal bupivacaine) in Adductor Canal Blocks (ACB) for peri-operative pain control following a total knee arthroplasty (TKA) procedure. Specifically, the investigators look to see if Exparel ACB reduces opioid requirement use post-operatively, reduces pain scores post-operatively, provides earlier mobilization, and decreases length of hospital stay. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04910165
Study type	Interventional
Source	St. Luke's Hospital, Pennsylvania
Contact
Status	Completed
Phase	Phase 3
Start date	June 1, 2020
Completion date	October 15, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05480111` - The Role of Quadratus Lumborum Blocks Following Minimally Invasive Hysterectomy	Phase 4
Completed	`NCT06129305` - Erector Spina Muscle Distance From the Skin at Different Thoracal Elevations
Completed	`NCT04401826` - Micro-surgical Treatment of Gummy Smile	N/A
Recruiting	`NCT04020133` - the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.	N/A
Completed	`NCT03023462` - Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair	N/A
Completed	`NCT03652103` - Efficiency of Erector Spinae Plane Block For Patients Undergoing Percutaneous Nephrolithotomy	Phase 4
Completed	`NCT03546738` - Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery	N/A
Withdrawn	`NCT03528343` - Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy	Phase 1/Phase 2
Terminated	`NCT03261193` - ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain	Phase 3
Completed	`NCT02525133` - Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty	Phase 3
Completed	`NCT03244540` - Regional Analgesia After Cesarean Section	Phase 4
Enrolling by invitation	`NCT05316168` - Post Operative Pain Management for ACL Reconstruction	Phase 3
Recruiting	`NCT04130464` - Intraperitoneal Infusion of Analgesic for Postoperative Pain Management	Phase 4
Enrolling by invitation	`NCT04574791` - Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty	N/A
Completed	`NCT04073069` - Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults	Phase 4
Completed	`NCT04526236` - Influence of Aging on Perioperative Methadone Dosing	Phase 4
Recruiting	`NCT05351229` - Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery	Phase 4
Enrolling by invitation	`NCT05543109` - Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block	N/A
Completed	`NCT05346588` - THRIVE Feasibility Trial	Phase 3
Completed	`NCT04919317` - Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty	Phase 2