Pain, Postoperative Clinical Trial
Official title:
Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure After Single-port Video-Assisted Thoracoscopic Surgery
NCT number | NCT03916120 |
Other study ID # | 2018-067 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | July 15, 2018 |
Est. completion date | January 15, 2019 |
Verified date | April 2019 |
Source | Second Affiliated Hospital, School of Medicine, Zhejiang University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.
Status | Completed |
Enrollment | 198 |
Est. completion date | January 15, 2019 |
Est. primary completion date | January 15, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Age = 70 and Age =18 - Selective operation lung section with video-assisted thoracic surgery (VATS) - III = American Society of Anesthesiologists classification (ASA classification) =I - Patients informed and agreed to join the study Exclusion Criteria: - Abnormal function of liver and kidney - Allergic- dependence history of alcohol, opioids and Local anesthetics - No noncompliance - Mental disease history,language communication disorder,cicatricial diathesis - Underweight or overweight(BMI<18 or >30) - Patients not suitable for clinical subjects for other reasons - Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation. - History of previous abnormal anaesthesia - Women during pregnancy or lactation |
Country | Name | City | State |
---|---|---|---|
China | The second affiliated hospital of Zhejiang University | Hangzhou | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Second Affiliated Hospital, School of Medicine, Zhejiang University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postoperative analgesic failure | Once patient experience at least one of the following situations: Bad patients sleep quality Require extra analgesic drug Low satisfaction with pain control Bolus times > 1 per hour |
8 a.m. at the first day after surgery. |
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