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Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department — ADAMOPA  

Pain Management Clinical Trial

Official title:
Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department: a Multicenter Randomized Controlled Double-blind Non-inferiority Trial

Clinical Trial Summary

In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.

Clinical Trial Description

This study is designed to assess whether IV morphine alone is non inferior to combination IV acetaminophen and morphine for the management of moderate to severe pain in the ED. Numeric rating scale pain score will be compared between those who receive morphine alone and who will receive acetaminophen and morphine at 15, 30, 45 and 60 min post first injection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04148495
Study type Interventional
Source Nantes University Hospital
Contact Céline LONGO, Doctor
Phone +33 2 53 48 20 44
Email celine.longo@chu-nantes.fr
Status Recruiting
Phase Phase 4
Start date December 3, 2019
Completion date June 3, 2024
View Details
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