Pain, Chronic Clinical Trial
Official title:
COMPARISON OF SYSTEMIC INFLAMMATION-RELATED HEMATOLOGICAL PARAMETERS IN ACUTE AND CHRONIC LOW BACK PAIN
NCT number | NCT04897620 |
Other study ID # | 2021-06-10 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 5, 2021 |
Est. completion date | June 5, 2021 |
The aim of the study is to compare the neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR), eosinophils to lymphocytes ratio (ELR), red blood cell distribution width (RDW), mean platelet volume (MPV), systemic immune inflammation index (SII), erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) which are the hematological parameters associated with systemic inflammation in acute and subacute/chronic low back pain. Secondary purpose; evaluation of the prognostic roles of hematological parameters associated with systemic inflammation in low back pain in predicting chronicity.This study is a retrospective case-control study. The data of patients who applied to the emergency department with the complaint of acute (less than 4 weeks) low back pain or to the Physical Medicine and Rehabilitation outpatient clinic with the complaint of subacute (lasting 4-12 weeks) or chronic (longer than 12 weeks) non-specific low back pain in the last 3 years will be scanned. The data of patients who applied with complaints other than medical conditions known to be associated with painful conditions and/or inflammatory response will be screened as a control group. The data of patients between the ages of 18-65 will be included in the study. In conclusion, the data of 150 patients who presented with acute non-specific low back pain, 150 patients who presented with subacute/chronic non-specific low back pain and 150 participants as the control group will be included in the study for use in analysis. Participants' age, gender, duration of low back pain (days), if evaluated, conditions associated with low back pain in cases with subacute/chronic pain, ESR, CRP, RDW, MPV, neutrophil count, lymphocyte count, eosinophil count and platelet count in blood tests at admission examinations will be recorded. NLR will be calculated by dividing the number of neutrophils by the number of lymphocytes, PLR by dividing the number of platelets by the number of lymphocytes, ELR by dividing the number of eosinophils by the number of lymphocytes, and SII by the formula "platelet numberxneutrophil number/lymphocyte number".
Status | Recruiting |
Enrollment | 450 |
Est. completion date | June 5, 2021 |
Est. primary completion date | June 5, 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - The data of patients who applied to the emergency department with the complaint of acute (less than 4 weeks) low back pain or to the Physical Medicine and Rehabilitation outpatient clinic with the complaint of subacute (lasting 4-12 weeks) or chronic (longer than 12 weeks) non-specific low back pain in the last 3 years. - The data of patients between the ages of 18-65. Exclusion Criteria: - Patients who have systemic diseases or internal organ pathologies that may cause low back pain, acute/chronic infection, malignancy, rheumatic disease or systemic diseases that may change the hematological inflammation parameters, which are evaluation parameters, - Patients who have severe neurological involvement findings in imaging examinations or clinical examination, - Patients who have a history of surgical procedures for the lumbar region in the last 6 months - Patients those missing one or more of the parameters planned to be evaluated within the scope of the screened data. |
Country | Name | City | State |
---|---|---|---|
Turkey | Ufuk University | Ankara | Çankaya |
Lead Sponsor | Collaborator |
---|---|
Ufuk University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Erythrocyte sedimentation rate | The erythrocyte sedimentation rate value in blood tests at admission examinations. | 1 month | |
Primary | C reactive protein | The C reactive protein value in blood tests at admission examinations. | 1 month | |
Primary | Red blood cell distribution width | The red blood cell distribution width value in blood tests at admission examinations. | 1 month | |
Primary | Mean platelet volume | The mean platelet volume value in blood tests at admission examinations. | 1 month | |
Primary | Neutrophils to lymphocytes ratio (NLR) | NLR is calculated by dividing the number of neutrophils by the number of lymphocytes. | 1 month | |
Primary | Platelets to lymphocytes ratio (PLR) | PLR is calculated by dividing the number of platelets by the number of lymphocytes. | 1 month | |
Primary | Eosinophils to lymphocytes ratio (ELR) | ELR is calculated by dividing the number of eosinophils by the number of lymphocytes. | 1 month | |
Primary | Systemic immune inflammation index (SII) | SII is calculated by the formula "platelet numberxneutrophil number/lymphocyte number. | 1 month |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05452499 -
Pain Neuroscience Education and Therapeutic Exercise as a Treatment for Breast Cancer Survivors Living With Sequelae
|
N/A | |
Recruiting |
NCT05037682 -
Pain and Opioid Management in Older Adults
|
N/A | |
Completed |
NCT04080037 -
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
|
N/A | |
Recruiting |
NCT05382962 -
iCanCope With Post-Operative Pain (iCanCope PostOp)
|
N/A | |
Recruiting |
NCT04285112 -
SPRINT: Signature for Pain Recovery IN Teens
|
||
Active, not recruiting |
NCT04850079 -
EHR Precision Drug Treatment in Neonates
|
||
Completed |
NCT03271151 -
Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
|
Phase 4 | |
Completed |
NCT03272139 -
Interscalene Block Versus Superior Trunk Block
|
Phase 4 | |
Completed |
NCT03886142 -
Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis
|
N/A | |
Recruiting |
NCT05761392 -
APP-based Precise Management System of Chronic Intractable Pain
|
N/A | |
Recruiting |
NCT05877157 -
Pain AND Opioids After Surgery
|
||
Completed |
NCT03947749 -
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain
|
||
Completed |
NCT03280017 -
Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain
|
Phase 4 | |
Recruiting |
NCT04874038 -
Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)
|
Phase 3 | |
Completed |
NCT04280796 -
Changes in Affective Pain Processing in Human Volunteers
|
N/A | |
Withdrawn |
NCT05125978 -
Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain
|
Phase 2 | |
Not yet recruiting |
NCT04328805 -
Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome.
|
Phase 4 | |
Completed |
NCT04976738 -
A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain
|
Phase 1/Phase 2 | |
Completed |
NCT04089618 -
Meditation Based Lifestyle Modification in Chronic Pain
|
N/A | |
Recruiting |
NCT05699837 -
Alpha Entrainment for Pain and Sleep (Extension)
|
N/A |