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Pain, Chronic clinical trials

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NCT ID: NCT03437460 Suspended - Pain, Chronic Clinical Trials

The Economic and Cognitive Effects of Pain Reduction

Start date: May 10, 2017
Phase: N/A
Study type: Interventional

Physical pain is a common but largely overlooked aspect of the lives of the poor. Not only does pain directly reduce life quality and happiness, it may also hamper cognitive function and, consequently, decision-making, productivity, and earnings. Workers with chronic pain may work fewer days, take longer breaks, and make less-considered choices regarding inputs; all outcomes that would reduce output and lead to greater impoverishment or impede the productivity and profitability of microenterprises and firms. The investigators will take the first steps in understanding the broader causal impact of physical pain on the cognitive and economic lives of the poor via a randomized controlled trial (RCT). 450 low-income women in Chennai, India, will be assigned to one of three treatment arms: 600 mg of over-the-counter pain medication, a placebo pill, or no medication. The research will quantify the causal impact of reduced pain on previously unstudied outcomes essential to escaping poverty including cognitive function, productivity, and earnings.

NCT ID: NCT03421951 Enrolling by invitation - Pain, Chronic Clinical Trials

Change in Pain and Quality of Life Following SCS for Chronic Pain

BURST
Start date: November 1, 2017
Phase: N/A
Study type: Observational

Study Title Subject-reported treatment efficacy and procedure satisfaction (steps) study.BURST study- a prospective observational clinical study examining the changes in quality of life and pain following spinal cord stimulation for the treatment of chronic intractable lower back and lower limb pain.

NCT ID: NCT03421522 Not yet recruiting - Breast Cancer Clinical Trials

Intercostobrachial Nerve Sparing to Reduce Post-Surgical Pain

INSPIRE
Start date: April 1, 2018
Phase: N/A
Study type: Interventional

Sacrifice of the intercostobrachial nerve (ICBN) during surgery is associated with development of persistent post-surgical pain (PPSP), which affects up to 60% of breast cancer surgery patients. A large, definitive trial is needed to establish whether nerve preservation techniques are effective in reducing post-surgical pain after breast cancer surgery. If the effect of ICBN preservation is consistent with observational studies, the absolute reduction of rates of persistent pain would be considerable.The primary objective is to determine the effect of ICBN preservation, versus usual care, on the prevalence and intensity of PPSP at one year after breast cancer surgery involving axillary lymph node dissection (ALND).

NCT ID: NCT03400384 Not yet recruiting - Health Behavior Clinical Trials

Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population

TAPERING
Start date: January 2018
Phase: N/A
Study type: Interventional

To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.

NCT ID: NCT03380104 Not yet recruiting - Pain, Chronic Clinical Trials

Intradural Percutaneous Stimulation

Start date: December 25, 2017
Phase: N/A
Study type: Interventional

The purpose of the study is to test the effects of intradural, spinal cord stimulation using a device placed in the same manner as a lumbar drain performed during a standard epidural spinal cord stimulation (SCS) trial routinely performed prior permanent lead and stimulation device implantation.

NCT ID: NCT03351010 Not yet recruiting - Pain, Chronic Clinical Trials

Mindfulness for Pain Management in Patients With Cancer

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Using pharmacologic agents are often effective to treat patients with cancer pain, but there are associated with serious side-effects and risks of dependence and addiction. The Thai Buddhism-based Mindfulness (TBbM) intervention created by a widely respected Buddhist monk focuses on testing a meditation technique to manage pain. If effective, millions of patients who suffer with cancer pain will benefit from use of a safe, culturally appropriate, non-pharmacologic approach to pain management.

NCT ID: NCT03346408 Recruiting - Pain, Chronic Clinical Trials

Dependence on Analgesics in Chronic Non-cancer Pain

DISCORDANCE
Start date: November 4, 2017
Phase: N/A
Study type: Observational

The identification of an addiction to opioid analgesics has become strong recommendation for the purpose of improving the clinical management of the patients. However, the success of the patient's clinical management, in terms of analgesia and treatment of drug dependence, rests on the acceptance of this management by the patient himself. The main objective of this study is to evaluate the factors associated to the discrepancy between the assessment of dependence on analgesic drugs by the algologist and the perception that the patient with non-cancer chronic pain has of this dependence.

NCT ID: NCT03322007 Not yet recruiting - Pain, Chronic Clinical Trials

A Pilot Trial of Scrambler Therapy for Pain Associated With Pancreas Cancer

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

BACKGROUND: Pain is the predominant and most feared symptom of pancreas cancer, and is often incompletely relieved. Scrambler Therapy is a new way of treating pain by providing "non-pain" information to confuse the nervous system and reset the damaged nerve pathways. It has been useful in treating many types of pain, but has not been adequately tested in the pain associated with pancreas cancer. OBJECTIVE: The goal of this study is to evaluate the effect of Scrambler Therapy on typical abdominal pain associated with pancreas cancer. HYPOTHESIS: We hypothesize that pain scores from day 0 (pre) to day 28 (post) will be reduced by at least 33%, e.g. from 6/10 to 4/10. METHODS: 20 patients, with expected data from 18 due to drop out of 2, will be treated with Scrambler Therapy using the standard methods of 45 minute sessions for 10 treatments. OUTCOMES: We will record data using the Brief Pain Inventory, and EORTC Quality of Life Questionnaire-Pancreas 26 to see if we obtain at least a 33% reduction in pain. This will inform future randomized trials of Scrambler Therapy versus traditional methods such a celiac plexus blocks.

NCT ID: NCT03318250 Not yet recruiting - Neuropathic Pain Clinical Trials

TransGrade Multimodal Neuromodulation of the Dorsal Root Ganglion Ensemble for Refractory Neuropathic Pain

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This a single center study comparing two forms of electrical stimulation: sub-sensory burst stimulation (DRG-Burst3D) and standard low frequency stimulation (DRG-LF) in the dorsal root ganglion of subjects diagnosed with neuropathic pain

NCT ID: NCT03310138 Recruiting - Pain, Chronic Clinical Trials

rTMS for Treatment of Pain and Craving

Start date: July 6, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to develop repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for pain in individuals on prescription opioid medication. Repetitive TMS is a non-invasive technique that uses magnetic pulses to temporarily stimulate specific brain areas in awake people (without the need for surgery, anesthetic, or other invasive procedures). This study will test whether 10 days of rTMS over the prefrontal cortex can produce a reduction in perception of pain and the desire to use opiates. TMS has been approved by the FDA as an investigational tool as well a therapy for depression.