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Pain, Chronic clinical trials

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NCT ID: NCT03629197 Recruiting - Opioid Use Clinical Trials

Improving Communication About Pain and Opioids

Start date: July 12, 2018
Phase: N/A
Study type: Interventional

The overall goal of this protocol is to pilot test a clinician training intervention that uses standardized patients (trained actors playing patient roles) as instructors who impart communication skills to primary care clinicians. This project will conduct a pilot clinical trial of the intervention developed by the primary investigator in order to evaluate intervention feasibility and generate data to plan a subsequent fully-powered, multisite trial. Primary care clinicians will be randomized to receive either the intervention or control; 48 patients (2 per clinician) will then be recorded during clinic visits with study clinicians and will provide data on post-visit perceptions and health outcomes. Study hypotheses are that visits with clinicians who receive the intervention (versus control) will be associated with more frequent use of targeted communication skills, lower probability of high-risk opioid prescribing, higher patient-reported agreement with treatment plan, and lower pain interference 2 months later.

NCT ID: NCT03597737 Not yet recruiting - Oncology Clinical Trials

Utility of an APP for the Monitoring of Irruptive Oncological Pain

Start date: August 5, 2018
Phase: N/A
Study type: Interventional

The present investigation aims at exploring the effect of including a pain app called Pain Monitor irruptive oncological pain for chronic pain patients' daily monitoring. Two conditions will be set: 1. usual treatment (waiting list) 2. usual treatment + APP

NCT ID: NCT03581591 Recruiting - Pain, Chronic Clinical Trials

Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets

Start date: January 31, 2018
Phase: Phase 3
Study type: Interventional

A 52 week, open label trial to assess the safety and efficacy of KRN23, an investigational antibody to FGF23, in a single pediatric patient with Epidermal Nevus Syndrome(ENS) and associated hypophosphatemic rickets

NCT ID: NCT03569865 Not yet recruiting - Osteoarthritis Clinical Trials

Audio-visual Stimulation: Sleep Dose Response

Start date: October 2018
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) pain affects 50 percent of older adults, more than half of whom also experience significant sleep disturbance. This study examines the impact of an innovative audiovisual stimulation (AVS) program on human brainwaves, and its usefulness to improve sleep. The AVS intervention, if demonstrated to be efficacious for sleep promotion, could benefit millions of people worldwide.

NCT ID: NCT03543085 Recruiting - Pain, Chronic Clinical Trials

Ultra-high Frequency (500 KHz) Spinal Cord Stimulation for Treatment of Chronic Back Pain or Lower Limb Pain

Start date: April 12, 2018
Phase: N/A
Study type: Interventional

This study is a prospective, single-arm, open label, single center to confirm the effectiveness and safety of an ultra-high frequency (500 KHz) spinal cord stimulation in patients with chronic back pain or lower limb pain.

NCT ID: NCT03521960 Recruiting - Clinical trials for Opioid-Related Disorders

Buspirone for Opioid Tapering

Start date: May 30, 2018
Phase: Phase 1
Study type: Interventional

This is a pilot study to collect preliminary data to support a grant application. The goal of the study is to evaluate whether the Food and Drug Administration (FDA)-approved and generically-available medication buspirone reduces symptoms of opioid withdrawal among patients undergoing a clinically-indicated and supervised taper from their opioid pain medications. This is premised on strong preclinical scientific support but has not yet be well-examined in humans.

NCT ID: NCT03502421 Not yet recruiting - Pain, Chronic Clinical Trials

Ketamine Sickle Cell Disease

Start date: September 1, 2018
Phase: Phase 3
Study type: Interventional

Sickle cell disease (SCD) often results in acute vaso-occlusive crisis (VOC), an obstruction of blood vessels resulting in ischemic injury and pain. The pain experienced during these episodes is due to a wide range of pathophysiological processes. Though recent studies have begun to unravel the underlying mechanisms of these processes, literature focused on pain management for sickle cell disease is scarce. Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) remain the predominate treatment for VOC. However, the efficacy of these treatments has come into question. A large sub-set of patients with SCD report continued pain despite treatment with opioids. Tolerance and opioid-induced hyperalgesia (OIH) may be responsible for unresponsiveness to opioid-centric treatment modalities. New classes of drugs are being tested to prevent and treat acute pain associated with SCD, but in the meantime physicians are looking to existing therapies to bridge the gap. The N-methyl-d-aspartate (NMDA) receptor has been implicated in both tolerance and OIH. As a NMDA receptor agonist, ketamine has been shown to modulate opioid tolerance and OIH in animal models and clinical settings. Ketamine utilized as a low dose continuous infusion could benefit patients with SCD related pain that are unresponsive to opioid analgesics. Based on limited studies of adjuvant ketamine use for pain management, low-dose ketamine continuous infusion appears safe. Further clinical investigations are warranted to fully support the use of low-dose ketamine infusion in patients with SCD-related pain.

NCT ID: NCT03487822 Recruiting - Pain, Chronic Clinical Trials

A Personalized Self-Management Program for Older Adults With Chronic Pain and Negative Emotions

Start date: August 8, 2017
Phase: N/A
Study type: Interventional

This study examines the effects of PATH-Pain on emotion regulation to improve self-management of pain and pain-related disability in older adults with chronic pain, negative emotions, and cognitive impairment. Half the participants will receive the intervention, and half the participants will receive usual care with education. Intervention subjects are hypothesized to have significantly less pain-related disability versus usual care subjects after 24 weeks.

NCT ID: NCT03480620 Recruiting - Pain, Chronic Clinical Trials

Post Discharge Online Telerehabilitation Program

Start date: February 9, 2018
Phase: N/A
Study type: Interventional

This study will evaluate the sustainability of pain and functional outcomes along with return to opioid use in a population of patients that successfully completed a comprehensive interdisciplinary pain rehabilitation program. In addition, this study will compare outcomes sustainability and return to opioid use between pain program graduates who receive post discharge self-management resources consisting of a DVD with videos of recommended flexibility practice (standard of care) or access to an online telerehabilitation platform that provides patients with access to the flexibility practice videos on a variety of telecommunication devices (e.g., computer, smart phone, tablet).

NCT ID: NCT03474406 Recruiting - Cancer Clinical Trials

The Effectiveness of Cancer Pain Management in Siriraj Outpatient Pain Clinic

Start date: January 3, 2018
Study type: Observational [Patient Registry]

-Background: Cancer is one of the most common cause of death. Cancer pain is often cited as one of the most feared in cancer patients. Although, WHO guidelines have been provided to improve pain outcome, the results are still unsatisfied. In order to improve cancer pain management we consider to contribute a new guideline which includes interdisciplinary approach, early doing the pain interventions, breakthrough pain, education, high quality of pain assessment and contribute the effectiveness follow-up system