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Pain, Acute clinical trials

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NCT ID: NCT04274530 Recruiting - Pain, Postoperative Clinical Trials

Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial

COPE
Start date: January 25, 2021
Phase: N/A
Study type: Interventional

Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures. To study this relationship, patients will undergo cognitive behavioural therapy (CBT) which is designed to modify such thoughts with the goal of reducing ongoing pain and improving quality of life. The goal of this study is to determine if CBT, versus usual care, reduces the prevalence of moderate to severe persistent post-surgical pain (PPSP) over 12-months post-fracture in patients with an open or closed fracture of the appendicular skeleton, treated with internal fixation.

NCT ID: NCT04262362 Recruiting - Pain, Acute Clinical Trials

The Frequency Of Sodium Hypochlorite Extrusion During Endodontic Treatments

Start date: December 5, 2019
Phase:
Study type: Observational

Sodium hypochlorite is a commonly used irrigation agent. However, the solution may extrude beyond the apex of tooth and cause pain during the treatment.The aim of this prospective observational investigation is to determinate the frequency of the extrusion of sodtium hypochlorite in endodontically treated teeth.

NCT ID: NCT04244695 Recruiting - Pain, Acute Clinical Trials

Oral Steroid in Controlling Pain After TKA

Start date: September 1, 2019
Phase: Phase 4
Study type: Interventional

To compare efficacy of oral steroid in controlling pain after TKA

NCT ID: NCT04215757 Recruiting - Pain, Acute Clinical Trials

Low Dose Lignocaine Injections as a Treatment Option for Acute Lumbosacral Radiculopathy

Start date: January 20, 2019
Phase: N/A
Study type: Interventional

Low back pain is one of the most common ailments that plagues patients, with nearly 80% of the population developing some form of back pain in their lifetime. Up regulated sodium channels in the nerve root or dorsal root ganglion are the basic cause for the mechano-sensitization and injecting the drug in the peripheral end of the nerve will block these sodium channels, since functionally both ends of the pseudo unipolar neuron are the same.

NCT ID: NCT04137198 Recruiting - Analgesia Clinical Trials

Sufentanil Intranasal

Start date: January 22, 2020
Phase: Phase 4
Study type: Interventional

Study of the effects of intranasal sufentanil on patients presenting to the emergency department with acute post-traumatic pain.

NCT ID: NCT04114851 Recruiting - Anesthesia Clinical Trials

The Effects of Objective Estimation of Pain Response

Start date: November 30, 2019
Phase: N/A
Study type: Interventional

There are different types of pain generators that give different pain symptoms. In anesthesia and surgery, the pain generator in connection with, for example, surgical procedures is referred to as nociceptive pain. However, there is not enough evidence to support that these physiological changes are direct signs of nociceptive stimulation. The same changes can be seen with an autonomous stress trigger of origin other than just nociceptive stimulation. This means that healthcare professionals who provide anesthesia to patients during, for example, surgery may provide unnecessary pain relief drugs or do not provide pain relief when needed. This is also true in awake patients when pain is complex that, for example, concerns may increase the experience of pain and that healthcare professionals may even then misinterpret and provide more pain-relieving drugs despite the actual need for another drug or complementary treatment. Examples of these include heart rate variation, specific patterns in blood pressure and heart rate response, heart rate amplitude, heart rate range, skin sweating and pupil response. The reason why these changes have not been used to interpret nociceptive stimulation is directly linked to an absence of technology that makes it possible to collect data and interpret these changes. list a number of methods / techniques that are under development, one of which is the Nociception Level Index (NoL). NoL is an indexed value between 0 and 100 and is based on a non-linear combination of nociception-related physiological variables (including heart rate variation, plethysmograph pulse wave amplitude (PPGA) and changes in skin resistance). Possibly NoL is the first evidence-based clinical technology that can discriminate pain response when physiological response is not measured. The research field in the area of non-invasive objective monitoring of pain response in relation to patients' experience of pain is currently almost non-existent in anesthesia / anesthesia care This in turn can also lead to the development of patient safety both during anesthesia and after surgery at nursing department for example, patient-controlled and epidural pain relief in postoperative pain care. investigators intend to study the variation of the NoL index linked to the need for opioids during anesthesia and also after completed anesthesia when the patient wakes up and is in the ward.

NCT ID: NCT04042545 Recruiting - Quality of Life Clinical Trials

Safety and Efficacy of Inhaled Cannabis For the Uncontrolled Pain Relief in Patients With Advanced Cancer

PLENITUDE
Start date: July 30, 2020
Phase: Phase 2
Study type: Interventional

This phase 2 multicenter clinical trial assess the safety and efficacy of inhaled PPP001 to relieve the pain in 78 advanced cancer patients with uncontrolled symptoms. This is a 4-week treatment period study followed by an open label period of 1 year.

NCT ID: NCT03997019 Recruiting - Pain, Acute Clinical Trials

Erector Spinae Plane Block in Cardiac Surgery

Start date: February 15, 2019
Phase: N/A
Study type: Interventional

ultrasound guided bilateral erector spinae plane block will be used as adjuvant to general anaesthesia in cardiac surgery

NCT ID: NCT03944564 Recruiting - Pain, Acute Clinical Trials

Cognitive and Motor Benefits of Standing

KOGIS
Start date: September 10, 2019
Phase: N/A
Study type: Interventional

Upright-working has been proven to benefit health by combating the negative effects of physical inactivity. However, long-term commitment to static standing regimens may be limited due to symptoms of musculoskeletal fatigue that may develop during prolonged static standing in the absence of facilitated weight shifting. We propose a dynamic standing approach (working while standing accompanied by small periodic stepping movements) as a more tolerable and thereby more applicative lifestyle modification.

NCT ID: NCT03853460 Recruiting - Pain, Acute Clinical Trials

Bilateral Quadraus LUMBORUM Block in Patients Under Going Cystectomy

Start date: October 30, 2019
Phase: N/A
Study type: Interventional

ultrasound guided quadratus lumborum will be given for patients under going partial or complete urinary bladder removal.