Overweight and Obesity Clinical Trial
Official title:
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults: A Neurophysiological and Resting Functional Magnetic Resonance Study (rfMRI)
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to compare the effect of a ketogenic diet versus ketone ester supplementation on motor cortex plasticity, resting brain function and structure, and metabolic and neuroendocrine responses.
The study initially makes a bold attempt to explore whether the ketone supplementation would induce improvements in the overweight/ obese population's brain health via altering motor cortex plasticity, brain function and structure, and metabolic and neuroendocrine pathways. The study's aims include: - assessing changes in brain plasticity associated with excessive body weight and/or obesity. - evaluating the potential of ketone monoester supplementation in enhancing brain plasticity. - evaluating the potential of ketone monoester supplementation in correcting impaired brain plasticity due to excessive body weight. - evaluating the impact of short-term ketogenic dieting and ketone monoester supplementation on brain plasticity. - investigating structural and functional brain adaptations to short-term ketogenic dieting and ketone supplementation. - assessing the relationship between changes in brain plasticity and the brain's structural and functional adaptations and changes in circulating levels of brain-derived neurotrophic factors and key central acting hormones (i.e., insulin and leptin) due to ketogenic dieting and ketone monoester supplementation. ;
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