EXerCise wEight Loss

Overweight and Obesity Clinical Trial

— EXCEL  

Official title:

The Effects of a Home-based Resistance Training Programme on Body Composition and Muscle Function During Weight Loss in People With Overweight or Obesity: a Randomised Controlled Pilot Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05702840
• Other study ID #: EXerCise wEight Loss Study
• Status: Completed
• Phase: N/A
• Start date: February 1, 2023
• Est. completion date: February 1, 2024

Study information

• Verified date: February 2024
• Source: University of Glasgow
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: February 1, 2024
• Est. primary completion date: February 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Obesity or overweight (BMI = 25kg/m2).
• Passing the Physical Activity Readiness Questionnaire (PAR-q+)

Exclusion Criteria:

• Currently take part in more than 1.5 hours of structured exercise per week.
• Having recently (<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss.
• Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months.
• Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Related Conditions & MeSH terms

• Obesity
• Overweight
• Overweight and Obesity
• Weight Loss

Intervention

Behavioral:
• Resistance exercise training + weight loss group
Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period
• Weight loss only group (WL)
Only following the weight watchers weight loss programme for a 12-week period

Locations

Country	Name	City	State
United Kingdom	Stuart Robert Gray	Glasgow

Sponsors (1)

Lead Sponsor	Collaborator
University of Glasgow

Country where clinical trial is conducted

United Kingdom, 

References & Publications (17)

An R, Ji M, Zhang S. Global warming and obesity: a systematic review. Obes Rev. 2018 Feb;19(2):150-163. doi: 10.1111/obr.12624. Epub 2017 Oct 4. — View Citation

Ashton RE, Tew GA, Aning JJ, Gilbert SE, Lewis L, Saxton JM. Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: systematic review with meta-analysis. Br J Sports Med. 2020 Mar;54(6):341-348. doi: 10.1136/bjsports-2017-098970. Epub 2018 Jun 22. — View Citation

Cava E, Yeat NC, Mittendorfer B. Preserving Healthy Muscle during Weight Loss. Adv Nutr. 2017 May 15;8(3):511-519. doi: 10.3945/an.116.014506. Print 2017 May. — View Citation

Cornelissen VA, Fagard RH, Coeckelberghs E, Vanhees L. Impact of resistance training on blood pressure and other cardiovascular risk factors: a meta-analysis of randomized, controlled trials. Hypertension. 2011 Nov;58(5):950-8. doi: 10.1161/HYPERTENSIONAHA.111.177071. Epub 2011 Sep 6. — View Citation

Enriquez Guerrero A, San Mauro Martin I, Garicano Vilar E, Camina Martin MA. Effectiveness of an intermittent fasting diet versus continuous energy restriction on anthropometric measurements, body composition and lipid profile in overweight and obese adults: a meta-analysis. Eur J Clin Nutr. 2021 Jul;75(7):1024-1039. doi: 10.1038/s41430-020-00821-1. Epub 2020 Dec 9. — View Citation

Ge L, Sadeghirad B, Ball GDC, da Costa BR, Hitchcock CL, Svendrovski A, Kiflen R, Quadri K, Kwon HY, Karamouzian M, Adams-Webber T, Ahmed W, Damanhoury S, Zeraatkar D, Nikolakopoulou A, Tsuyuki RT, Tian J, Yang K, Guyatt GH, Johnston BC. Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials. BMJ. 2020 Apr 1;369:m696. doi: 10.1136/bmj.m696. Erratum In: BMJ. 2020 Aug 5;370:m3095. — View Citation

James PT, Leach R, Kalamara E, Shayeghi M. The worldwide obesity epidemic. Obes Res. 2001 Nov;9 Suppl 4:228S-233S. doi: 10.1038/oby.2001.123. — View Citation

Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018 Feb 10;391(10120):541-551. doi: 10.1016/S0140-6736(17)33102-1. Epub 2017 Dec 5. — View Citation

Mikesky AE, Topp R, Wigglesworth JK, Harsha DM, Edwards JE. Efficacy of a home-based training program for older adults using elastic tubing. Eur J Appl Physiol Occup Physiol. 1994;69(4):316-20. doi: 10.1007/BF00392037. — View Citation

NIH Consensus statement. Bioelectrical impedance analysis in body composition measurement. National Institutes of Health Technology Assessment Conference Statement. December 12-14, 1994. Nutrition. 1996 Nov-Dec;12(11-12):749-62. — View Citation

Pellegrini M, Cioffi I, Evangelista A, Ponzo V, Goitre I, Ciccone G, Ghigo E, Bo S. Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis. Rev Endocr Metab Disord. 2020 Mar;21(1):17-33. doi: 10.1007/s11154-019-09524-w. Erratum In: Rev Endocr Metab Disord. 2020 Feb 18;: — View Citation

Plotnikoff RC, Eves N, Jung M, Sigal RJ, Padwal R, Karunamuni N. Multicomponent, home-based resistance training for obese adults with type 2 diabetes: a randomized controlled trial. Int J Obes (Lond). 2010 Dec;34(12):1733-41. doi: 10.1038/ijo.2010.109. Epub 2010 Jun 8. — View Citation

Sajoux I, Lorenzo PM, Gomez-Arbelaez D, Zulet MA, Abete I, Castro AI, Baltar J, Portillo MP, Tinahones FJ, Martinez JA, Crujeiras AB, Casanueva FF. Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity. Nutrients. 2019 Oct 4;11(10):2368. doi: 10.3390/nu11102368. — View Citation

Siervo M, Montagnese C, Mathers JC, Soroka KR, Stephan BC, Wells JC. Sugar consumption and global prevalence of obesity and hypertension: an ecological analysis. Public Health Nutr. 2014 Mar;17(3):587-96. doi: 10.1017/S1368980013000141. Epub 2013 Feb 18. — View Citation

Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a Disease. Med Clin North Am. 2018 Jan;102(1):13-33. doi: 10.1016/j.mcna.2017.08.004. Epub 2017 Oct 21. — View Citation

Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr. 2006 Sep;84(3):475-82. doi: 10.1093/ajcn/84.3.475. — View Citation

Zion AS, De Meersman R, Diamond BE, Bloomfield DM. A home-based resistance-training program using elastic bands for elderly patients with orthostatic hypotension. Clin Auton Res. 2003 Aug;13(4):286-92. doi: 10.1007/s10286-003-0117-3. — View Citation

* Note: There are 17 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in whole body lean mass	whole body lean mass measured via bio-electrical impedance	Change from baseline to 12 weeks
Secondary	Change in whole body fat mass	whole body fat mass measured via bio-electrical impedance	Change from baseline to 12 weeks
Secondary	Change in body mass	body mass measured on scales	Change from baseline to 12 weeks
Secondary	Change in vastus lateralis muscle thickness	Muscle thickness of the vastus lateralis muscle measured via ultrasound	Change from baseline to 12 weeks
Secondary	Change in knee extensor maximal isometric torque	Knee extensor maximal isometric torque measured during a maximal voluntary contraction	Change from baseline to 12 weeks
Secondary	Change in grip strength	Grip strength measured with a hand held dynamometer	Change from baseline to 12 weeks
Secondary	Change in functional physical abilities	A 30-second sit-to-stand test measured functional abilities	Change from baseline to 12 weeks