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Methyl-donor Nutrient Supplementation and Methylation Profile in Lupus Patients With Obesity

Overweight and Obesity Clinical Trial

Official title:
Effect of Methyl-donor Nutrient Supplementation on Methylation Profile of Inflammatory-related Genes in Lupus Patients With Obesity: a Clinical Trial

Clinical Trial Summary

Dietary supplementation with methyl donors has been demonstrated to increase DNA methylation in leucocytes whereas a limited dietary intake of methyl donors was associated with DNA hypomethylation. Considering SLE disease, previously study showed that high doses of vitamin B6 and folate were associated with less severe SLE. Furthermore, some evidences reported a relatively high incidence of decreased serum B12 levels in rheumatic patients. This led to the suggestion that diets rich in methyl group donors could have beneficial effects on SLE.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05097365
Study type Interventional
Source University of Sao Paulo
Contact
Status Enrolling by invitation
Phase N/A
Start date January 1, 2022
Completion date December 31, 2026
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