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Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS

Ovarian Hyperstimulation Syndrome Clinical Trial

Official title:
The Randomized Controlled Trial Study of Letrozole in the Prevention of Medium and Severe Ovarian Hyperstimulation Syndrome in Invitro Fertilization Treatment

Clinical Trial Summary

Letrozole is one kind of aromatase inhibitors which may have effect on decrease estrogen in luteal phase and inhibit the luteal function of ovary. In 2009, Letrozole was reported as one candidate for the treatment or prevention of ovarian hyperstimulation syndrome.

Clinical Trial Description

Letrozole was proved to be effective in decreasing the estradiol level of luteal phase after ovum picked up. In this randomized controlled study, investigators try to observe the effectiveness of letrozole on decreasing the incidence of early ovarian hyperstimulation syndrome and vascular epithelium growth factor level of women with high ovarian hyperstimulation syndrome risks. ;

Study Design

Related Conditions & MeSH terms

  • Ovarian Hyperstimulation Syndrome
  • Syndrome
Clinical Trial Details
NCT number NCT02670304
Study type Interventional
Source First Affiliated Hospital, Sun Yat-Sen University
Contact
Status Completed
Phase Phase 4
Start date January 2012
Completion date August 2013
View Details
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